GO Annotations Graph

• Symbol: Ezr
• Name: ezrin
• ID: MGI:98931

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0008092	cytoskeletal protein binding	IEA	J:72247
Molecular Function	GO:0097718	disordered domain specific binding	IDA	J:240276
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:240276
Molecular Function	GO:0005515	protein binding	IPI	J:182870
Molecular Function	GO:0005515	protein binding	IPI	J:255604
Molecular Function	GO:0005515	protein binding	IPI	J:77485
Molecular Function	GO:0005515	protein binding	IPI	J:206363
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0051018	protein kinase A binding	ISO	J:164563
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0034237	protein kinase A regulatory subunit binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044548	S100 protein binding	ISO	J:164563
Cellular Component	GO:0015629	actin cytoskeleton	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IBA	J:265628
Cellular Component	GO:0045177	apical part of cell	IDA	J:52936
Cellular Component	GO:0045177	apical part of cell	IDA	J:88943
Cellular Component	GO:0045177	apical part of cell	IDA	J:52936
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:87186
Cellular Component	GO:0097449	astrocyte projection	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0005903	brush border	IDA	J:211887
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0071944	cell periphery	ISO	J:164563
Cellular Component	GO:0042995	cell projection	ISO	J:164563
Cellular Component	GO:0051286	cell tip	ISO	J:155856
Cellular Component	GO:0036064	ciliary basal body	IDA	J:88943
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0098592	cytoplasmic side of apical plasma membrane	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:164563
Cellular Component	GO:0001650	fibrillar center	ISO	J:164563
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0030175	filopodium	ISO	J:155856
Cellular Component	GO:0030175	filopodium	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	ISO	J:164563
Cellular Component	GO:0001772	immunological synapse	ISO	J:164563
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:123097
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0044393	microspike	ISO	J:155856
Cellular Component	GO:0005902	microvillus	ISO	J:164563
Cellular Component	GO:0005902	microvillus	IDA	J:255604
Cellular Component	GO:0005902	microvillus	IBA	J:265628
Cellular Component	GO:0005902	microvillus	IDA	J:161201
Cellular Component	GO:0005902	microvillus	IDA	J:117056
Cellular Component	GO:0005902	microvillus	IDA	J:195630
Cellular Component	GO:0031528	microvillus membrane	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:206363
Cellular Component	GO:0005886	plasma membrane	IDA	J:169829
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001726	ruffle	ISO	J:164563
Cellular Component	GO:0097454	Schwann cell microvillus	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0001931	uropod	IDA	J:94032
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0051017	actin filament bundle assembly	ISO	J:164563
Biological Process	GO:0030953	astral microtubule organization	ISO	J:164563
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0043622	cortical microtubule organization	ISO	J:164563
Biological Process	GO:0051660	establishment of centrosome localization	ISO	J:164563
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:164563
Biological Process	GO:0035088	establishment or maintenance of apical/basal cell polarity	IMP	J:92210
Biological Process	GO:0046847	filopodium assembly	ISO	J:155856
Biological Process	GO:0046847	filopodium assembly	ISO	J:164563
Biological Process	GO:0001951	intestinal D-glucose absorption	IGI	J:219622
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0032703	negative regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:1903753	negative regulation of p38MAPK cascade	ISO	J:164563
Biological Process	GO:0050860	negative regulation of T cell receptor signaling pathway	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0048015	phosphatidylinositol-mediated signaling	ISO	J:164563
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	ISO	J:164563
Biological Process	GO:2000643	positive regulation of early endosome to late endosome transport	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0040018	positive regulation of multicellular organism growth	IGI	J:219622
Biological Process	GO:0045732	positive regulation of protein catabolic process	ISO	J:164563
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	ISO	J:164563
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	IBA	J:265628
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IGI	J:219622
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:264135
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:264135
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IMP	J:264135
Biological Process	GO:0098974	postsynaptic actin cytoskeleton organization	IDA	J:264135
Biological Process	GO:0010737	protein kinase A signaling	ISO	J:164563
Biological Process	GO:0072697	protein localization to cell cortex	ISO	J:164563
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0031503	protein-containing complex localization	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	IMP	J:104536
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IBA	J:265628
Biological Process	GO:0032532	regulation of microvillus length	IGI	J:219622
Biological Process	GO:1902115	regulation of organelle assembly	ISO	J:164563
Biological Process	GO:1902115	regulation of organelle assembly	IBA	J:265628
Biological Process	GO:0003376	sphingosine-1-phosphate receptor signaling pathway	ISO	J:164563
Biological Process	GO:1902896	terminal web assembly	IGI	J:219622