GO Annotations Graph

• Symbol: Xpa
• Name: xeroderma pigmentosum, complementation group A
• ID: MGI:99135

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005662	DNA replication factor A complex	ISO	J:164563
Cellular Component	GO:0045171	intercellular bridge	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0000110	nucleotide-excision repair factor 1 complex	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:84299
Biological Process	GO:0006284	base-excision repair	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IMP	J:48442
Biological Process	GO:0006281	DNA repair	IMP	J:76608
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:65265
Biological Process	GO:0035264	multicellular organism growth	IGI	J:181994
Biological Process	GO:0006289	nucleotide-excision repair	ISO	J:164563
Biological Process	GO:0006289	nucleotide-excision repair	IMP	J:76608
Biological Process	GO:0006289	nucleotide-excision repair	IMP	J:81189
Biological Process	GO:1901255	nucleotide-excision repair involved in interstrand cross-link repair	IBA	J:265628
Biological Process	GO:0000715	nucleotide-excision repair, DNA damage recognition	IBA	J:265628
Biological Process	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	IGI	J:181994
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0010506	regulation of autophagy	IMP	J:136907
Biological Process	GO:0006979	response to oxidative stress	IMP	J:76608
Biological Process	GO:0006979	response to oxidative stress	IMP	J:81189
Biological Process	GO:0009636	response to toxic substance	IMP	J:70351
Biological Process	GO:0009411	response to UV	IMP	J:112137
Biological Process	GO:0009650	UV protection	ISO	J:164563
Biological Process	GO:0070914	UV-damage excision repair	IBA	J:265628