GO Annotations Graph

• Symbol: Fasl
• Name: Fas ligand
• ID: MGI:99255

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005125	cytokine activity	IEA	J:60000
Molecular Function	GO:0005123	death receptor binding	ISO	J:155856
Molecular Function	GO:0005164	tumor necrosis factor receptor binding	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:224737
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:113553
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005764	lysosome	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:73065
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0097190	apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:95351
Biological Process	GO:0097190	apoptotic signaling pathway	IDA	J:17445
Biological Process	GO:0048388	endosomal lumen acidification	ISO	J:155856
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:155856
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IBA	J:265628
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:89131
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IDA	J:113782
Biological Process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:230059
Biological Process	GO:0006955	immune response	IEA	J:72247
Biological Process	GO:0006925	inflammatory cell apoptotic process	ISO	J:155856
Biological Process	GO:0030644	intracellular chloride ion homeostasis	ISO	J:155856
Biological Process	GO:0070266	necroptotic process	ISO	J:164563
Biological Process	GO:0097527	necroptotic signaling pathway	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:87682
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	J:265628
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:1905782	positive regulation of phosphatidylserine exposure on apoptotic cell surface	ISO	J:164563
Biological Process	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	ISO	J:230059
Biological Process	GO:0046666	retinal cell programmed cell death	IMP	J:85918
Biological Process	GO:0046666	retinal cell programmed cell death	IMP	J:85918
Biological Process	GO:0070231	T cell apoptotic process	ISO	J:164563