GO Annotations Graph

• Symbol: Prkci
• Name: protein kinase C, iota
• ID: MGI:99260

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004698	calcium-dependent protein kinase C activity	IEA	J:72245
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005543	phospholipid binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:247393
Molecular Function	GO:0005515	protein binding	IPI	J:194840
Molecular Function	GO:0005515	protein binding	IPI	J:225409
Molecular Function	GO:0005515	protein binding	IPI	J:225407
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004697	protein kinase C activity	IDA	J:148082
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0045177	apical part of cell	IDA	J:88495
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:113146
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:155856
Cellular Component	GO:0005903	brush border	IDA	J:300338
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:87877
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005737	cytoplasm	IDA	J:63657
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0045171	intercellular bridge	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0005634	nucleus	IDA	J:63657
Cellular Component	GO:0120157	PAR polarity complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0043220	Schmidt-Lanterman incisure	IDA	J:159103
Biological Process	GO:0007015	actin filament organization	IMP	J:92719
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0045216	cell-cell junction organization	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	IMP	J:148082
Biological Process	GO:0035089	establishment of apical/basal cell polarity	IMP	J:102364
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0042462	eye photoreceptor cell development	IMP	J:102364
Biological Process	GO:0048194	Golgi vesicle budding	ISO	J:155856
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2000353	positive regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:0060252	positive regulation of glial cell proliferation	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	IMP	J:148082
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	IMP	J:148082
Biological Process	GO:0008104	protein localization	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:148082
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	ISO	J:155856
Biological Process	GO:0070555	response to interleukin-1	ISO	J:155856
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856