GO Annotations Graph

• Symbol: Adora2a
• Name: adenosine A2a receptor
• ID: MGI:99402

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051393	alpha-actinin binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	ISO	J:155856
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	ISO	J:164563
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IBA	J:265628
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IMP	J:67550
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IMP	J:63086
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IDA	J:33119
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IDA	J:63612
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IDA	J:112280
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IDA	J:79146
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031802	type 5 metabotropic glutamate receptor binding	ISO	J:155856
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0030673	axolemma	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0012505	endomembrane system	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005882	intermediate filament	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:63612
Cellular Component	GO:0016020	membrane	IDA	J:33119
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:250701
Cellular Component	GO:0005886	plasma membrane	IDA	J:84007
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0048786	presynaptic active zone	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:142711
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:79146
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:33119
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI	J:79146
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:63086
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:112280
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	J:142711
Biological Process	GO:0097190	apoptotic signaling pathway	IMP	J:63086
Biological Process	GO:0048143	astrocyte activation	ISO	J:155856
Biological Process	GO:0042755	eating behavior	ISO	J:155856
Biological Process	GO:0042755	eating behavior	IGI	J:81841
Biological Process	GO:0060079	excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IBA	J:265628
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IGI	J:79146
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IMP	J:63086
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IDA	J:79146
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IMP	J:123805
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	ISO	J:250701
Biological Process	GO:0060080	inhibitory postsynaptic potential	IGI	J:60965
Biological Process	GO:0007626	locomotory behavior	ISO	J:155856
Biological Process	GO:0007626	locomotory behavior	IGI	J:63612
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IGI	J:102700
Biological Process	GO:0007626	locomotory behavior	IGI	J:81841
Biological Process	GO:0007626	locomotory behavior	IGI	J:67550
Biological Process	GO:0051899	membrane depolarization	ISO	J:155856
Biological Process	GO:0046636	negative regulation of alpha-beta T cell activation	IDA	J:142710
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0050728	negative regulation of inflammatory response	IGI	J:128038
Biological Process	GO:0040013	negative regulation of locomotion	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0043116	negative regulation of vascular permeability	ISO	J:155856
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission	ISO	J:155856
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IMP	J:63086
Biological Process	GO:0045938	positive regulation of circadian sleep/wake cycle, sleep	ISO	J:155856
Biological Process	GO:0014049	positive regulation of glutamate secretion	ISO	J:155856
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:155856
Biological Process	GO:0035815	positive regulation of renal sodium excretion	ISO	J:155856
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	IGI	J:112280
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	IDA	J:112280
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0035810	positive regulation of urine volume	ISO	J:155856
Biological Process	GO:0060134	prepulse inhibition	ISO	J:155856
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	ISO	J:155856
Biological Process	GO:0014061	regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0043279	response to alkaloid	ISO	J:155856
Biological Process	GO:0001975	response to amphetamine	IMP	J:67550
Biological Process	GO:0031000	response to caffeine	ISO	J:155856
Biological Process	GO:0010035	response to inorganic substance	IMP	J:250701
Biological Process	GO:0010035	response to inorganic substance	ISO	J:250701
Biological Process	GO:0014074	response to purine-containing compound	ISO	J:250701
Biological Process	GO:0014074	response to purine-containing compound	IMP	J:250701
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0007271	synaptic transmission, cholinergic	ISO	J:155856
Biological Process	GO:0001963	synaptic transmission, dopaminergic	IGI	J:81841
Biological Process	GO:0035249	synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0042311	vasodilation	ISO	J:155856