GO Annotations Graph

• Symbol: Adora2b
• Name: adenosine A2b receptor
• ID: MGI:99403

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001609	G protein-coupled adenosine receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IBA	J:265628
Molecular Function	GO:0004930	G protein-coupled receptor activity	IMP	J:113120
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256403
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256403
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:256403
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:256403
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:256403
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:84007
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	EXP	J:256403
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:256403
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:256403
Cellular Component	GO:0045202	synapse	IDA	J:256403
Cellular Component	GO:0045202	synapse	IDA	J:256403
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:113120
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:135978
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:135978
Biological Process	GO:0031668	cellular response to extracellular stimulus	IDA	J:17705
Biological Process	GO:0019934	cGMP-mediated signaling	IMP	J:135978
Biological Process	GO:0019934	cGMP-mediated signaling	IMP	J:135978
Biological Process	GO:0001973	G protein-coupled adenosine receptor signaling pathway	IEA	J:72247
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0043303	mast cell degranulation	IMP	J:132588
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0033605	positive regulation of catecholamine secretion	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0010753	positive regulation of cGMP-mediated signaling	IMP	J:135978
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:138722
Biological Process	GO:0002882	positive regulation of chronic inflammatory response to non-antigenic stimulus	IMP	J:113120
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:155856
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:155856
Biological Process	GO:0031284	positive regulation of guanylate cyclase activity	IMP	J:135978
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:155856
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IMP	J:138722
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:132588
Biological Process	GO:0010701	positive regulation of norepinephrine secretion	ISO	J:155856
Biological Process	GO:0010893	positive regulation of steroid biosynthetic process	ISO	J:155856
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	IMP	J:138722
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:256403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:256403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IDA	J:256403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:256403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	IMP	J:256403
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	EXP	J:256403
Biological Process	GO:0010906	regulation of glucose metabolic process	ISO	J:155856
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:135978
Biological Process	GO:0060087	relaxation of vascular associated smooth muscle	IMP	J:135978
Biological Process	GO:1990776	response to angiotensin	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042311	vasodilation	ISO	J:155856
Biological Process	GO:0042311	vasodilation	IBA	J:265628