GO Annotations Graph

• Symbol: Itpr2
• Name: inositol 1,4,5-triphosphate receptor 2
• ID: MGI:99418

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:72247
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0015278	calcium-release channel activity	IDA	J:19925
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	ISO	J:155856
Molecular Function	GO:0070679	inositol 1,4,5 trisphosphate binding	IBA	J:265628
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO	J:155856
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IBA	J:265628
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	J:121270
Molecular Function	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA	J:19925
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0035091	phosphatidylinositol binding	IBA	J:265628
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:121270
Molecular Function	GO:0035091	phosphatidylinositol binding	IDA	J:19925
Molecular Function	GO:0005515	protein binding	IPI	J:235425
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	IDA	J:51940
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:51940
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043209	myelin sheath	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:99797
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0030667	secretory granule membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006816	calcium ion transport	IDA	J:19925
Biological Process	GO:0071320	cellular response to cAMP	IDA	J:164619
Biological Process	GO:0071361	cellular response to ethanol	IMP	J:171210
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247