GO Annotations Graph

• Symbol: Nfe2l1
• Name: nuclear factor, erythroid derived 2,-like 1
• ID: MGI:99421

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	IDA	J:250015
Molecular Function	GO:0003682	chromatin binding	IDA	J:220017
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:252061
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:276393
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:162949
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:53336
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:186656
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IEA	J:72247
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:250015
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS	J:251998
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0008289	lipid binding	IEA	J:60000
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:220017
Molecular Function	GO:0005515	protein binding	IPI	J:252061
Molecular Function	GO:0005515	protein binding	IPI	J:178646
Molecular Function	GO:0005515	protein binding	IPI	J:252001
Molecular Function	GO:0005515	protein binding	IPI	J:85958
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:240280
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:240280
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:276393
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:162949
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:252061
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:53336
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP	J:186656
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:250015
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS	J:276498
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:265034
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:250015
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:223104
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:250015
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISS	J:283204
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	IDA	J:240280
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Biological Process	GO:0045454	cell redox homeostasis	IDA	J:252061
Biological Process	GO:0045454	cell redox homeostasis	IDA	J:276393
Biological Process	GO:0019725	cellular homeostasis	IMP	J:265034
Biological Process	GO:0071397	cellular response to cholesterol	IDA	J:250015
Biological Process	GO:0071397	cellular response to cholesterol	IMP	J:250015
Biological Process	GO:0070417	cellular response to cold	IMP	J:265034
Biological Process	GO:0071280	cellular response to copper ion	IMP	J:212052
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:162949
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:252061
Biological Process	GO:0034599	cellular response to oxidative stress	IDA	J:276393
Biological Process	GO:0042632	cholesterol homeostasis	IDA	J:250015
Biological Process	GO:0042632	cholesterol homeostasis	IMP	J:250015
Biological Process	GO:0008203	cholesterol metabolic process	IEA	J:60000
Biological Process	GO:0042883	cysteine transport	IMP	J:224339
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:46990
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	IMP	J:230118
Biological Process	GO:0021781	glial cell fate commitment	IDA	J:199442
Biological Process	GO:0051156	glucose 6-phosphate metabolic process	IMP	J:230118
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:224339
Biological Process	GO:0055088	lipid homeostasis	IMP	J:186656
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0000089	mitotic metaphase	IMP	J:203246
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISS	J:251998
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	IDA	J:250015
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:53336
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:276393
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:252061
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:212052
Biological Process	GO:0000209	protein polyubiquitination	IMP	J:186943
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0019217	regulation of fatty acid metabolic process	IMP	J:224339
Biological Process	GO:0010468	regulation of gene expression	IMP	J:230118
Biological Process	GO:0010468	regulation of gene expression	IMP	J:224339
Biological Process	GO:0010468	regulation of gene expression	IMP	J:251596
Biological Process	GO:0010906	regulation of glucose metabolic process	IMP	J:230118
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:250015
Biological Process	GO:0050727	regulation of inflammatory response	IMP	J:265034
Biological Process	GO:0019216	regulation of lipid metabolic process	IMP	J:224339
Biological Process	GO:0007088	regulation of mitotic nuclear division	IMP	J:203246
Biological Process	GO:1903353	regulation of nucleus organization	IMP	J:203246
Biological Process	GO:1901329	regulation of odontoblast differentiation	ISO	J:164563
Biological Process	GO:1901329	regulation of odontoblast differentiation	ISS	J:251998
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	IMP	J:265034
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	IMP	J:244981
Biological Process	GO:1905897	regulation of response to endoplasmic reticulum stress	IMP	J:265034
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:162949
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:244981
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:223104
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:203246
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:220017
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:220017
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:214539
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IDA	J:220017
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:214539
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IMP	J:186943
Biological Process	GO:0008202	steroid metabolic process	IEA	J:60000