GO Annotations Graph

• Symbol: Btc
• Name: betacellulin, epidermal growth factor family member
• ID: MGI:99439

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0008083	growth factor activity	ISO	J:155856
Molecular Function	GO:0048018	receptor ligand activity	IGI	J:138998
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:80421
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:22281
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:317052
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:319897
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	IDA	J:22281
Cellular Component	GO:0005615	extracellular space	ISO	J:80421
Cellular Component	GO:0005615	extracellular space	ISO	J:317052
Cellular Component	GO:0005615	extracellular space	IDA	J:319897
Cellular Component	GO:0016020	membrane	ISS	J:63016
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IDA	J:138998
Biological Process	GO:0008283	cell population proliferation	IGI	J:138998
Biological Process	GO:0008283	cell population proliferation	IGI	J:138998
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:22281
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:138998
Biological Process	GO:1904019	epithelial cell apoptotic process	IDA	J:138998
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:319897
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:317052
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IDA	J:138998
Biological Process	GO:0045597	positive regulation of cell differentiation	ISO	J:155856
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:138998
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:138998
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	IBA	J:265628
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:155856
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IBA	J:265628
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISS	J:63016
Biological Process	GO:0035810	positive regulation of urine volume	ISO	J:155856