GO Annotations Graph

• Symbol: Irs1
• Name: insulin receptor substrate 1
• ID: MGI:99454

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0005158	insulin receptor binding	IBA	J:265628
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IGI	J:38502
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:36742
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:44906
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:110842
Molecular Function	GO:0140677	molecular function activator activity	IMP	J:125968
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:81182
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:327403
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:164563
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	ISO	J:155856
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IBA	J:265628
Molecular Function	GO:0043548	phosphatidylinositol 3-kinase binding	IDA	J:107119
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:132675
Molecular Function	GO:0005515	protein binding	IPI	J:265618
Molecular Function	GO:0005515	protein binding	IPI	J:201303
Molecular Function	GO:0005515	protein binding	IPI	J:130473
Molecular Function	GO:0005515	protein binding	IPI	J:161178
Molecular Function	GO:0005515	protein binding	IPI	J:265598
Molecular Function	GO:0005515	protein binding	IPI	J:194550
Molecular Function	GO:0005515	protein binding	IPI	J:135557
Molecular Function	GO:0005515	protein binding	IPI	J:154728
Molecular Function	GO:0005515	protein binding	IPI	J:230404
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IDA	J:87936
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:36742
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IGI	J:38502
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	IDA	J:44906
Molecular Function	GO:0042169	SH2 domain binding	ISO	J:155856
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	ISO	J:155856
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:110842
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IMP	J:125968
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	IDA	J:81182
Molecular Function	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity	ISO	J:327403
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0036064	ciliary basal body	IDA	J:153289
Cellular Component	GO:0005737	cytoplasm	IDA	J:84783
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-198263
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-198275
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671830
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671841
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9603457
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005899	insulin receptor complex	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:84783
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:107119
Biological Process	GO:0016477	cell migration	IGI	J:124667
Biological Process	GO:0071398	cellular response to fatty acid	IMP	J:271696
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:107119
Biological Process	GO:0010631	epithelial cell migration	IGI	J:124667
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008286	insulin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0008286	insulin receptor signaling pathway	IGI	J:38502
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:306699
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:110842
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:21374
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:36742
Biological Process	GO:0008286	insulin receptor signaling pathway	IMP	J:110842
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:230404
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IMP	J:21373
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IDA	J:81182
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	IGI	J:21373
Biological Process	GO:0016042	lipid catabolic process	IMP	J:107119
Biological Process	GO:0030879	mammary gland development	IGI	J:124667
Biological Process	GO:0030879	mammary gland development	IGI	J:124667
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:155856
Biological Process	GO:0046676	negative regulation of insulin secretion	ISO	J:164563
Biological Process	GO:0090275	negative regulation of somatostatin secretion	ISO	J:155856
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IGI	J:124667
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	ISO	J:164563
Biological Process	GO:0070094	positive regulation of glucagon secretion	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0010907	positive regulation of glucose metabolic process	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002053	positive regulation of mesenchymal cell proliferation	IGI	J:124667
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	ISO	J:155856
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:107119
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:155856
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0043491	protein kinase B signaling	IGI	J:91846
Biological Process	GO:0034504	protein localization to nucleus	IMP	J:154728
Biological Process	GO:0034504	protein localization to nucleus	IDA	J:154728
Biological Process	GO:0010468	regulation of gene expression	IMP	J:107119
Biological Process	GO:0031000	response to caffeine	ISO	J:155856
Biological Process	GO:0032868	response to insulin	ISO	J:164563
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000