GO Annotations Graph

• Symbol: Mc4r
• Name: melanocortin 4 receptor
• ID: MGI:99457

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0042562	hormone binding	ISO	J:155856
Molecular Function	GO:0004977	melanocortin receptor activity	ISO	J:155856
Molecular Function	GO:0004977	melanocortin receptor activity	IDA	J:45497
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	ISO	J:164563
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	IBA	J:265628
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	IDA	J:45497
Molecular Function	GO:0042923	neuropeptide binding	ISO	J:164563
Molecular Function	GO:0017046	peptide hormone binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:87190
Molecular Function	GO:0005515	protein binding	IPI	J:45497
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0002024	diet induced thermogenesis	ISO	J:155856
Biological Process	GO:0006112	energy reserve metabolic process	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	ISO	J:155856
Biological Process	GO:0007631	feeding behavior	IMP	J:84073
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0030073	insulin secretion	IGI	J:129798
Biological Process	GO:2000252	negative regulation of feeding behavior	ISO	J:155856
Biological Process	GO:0045780	positive regulation of bone resorption	ISO	J:164563
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:117473
Biological Process	GO:1903998	regulation of eating behavior	IMP	J:306585
Biological Process	GO:0060259	regulation of feeding behavior	ISO	J:155856
Biological Process	GO:2000821	regulation of grooming behavior	ISO	J:155856
Biological Process	GO:0019222	regulation of metabolic process	IMP	J:84073
Biological Process	GO:0032868	response to insulin	IMP	J:129798
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	IMP	J:306585
Biological Process	GO:0007165	signal transduction	IEA	J:60000