GO Annotations Graph

• Symbol: Arrb1
• Name: arrestin, beta 1
• ID: MGI:99473

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0031691	alpha-1A adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031692	alpha-1B adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031701	angiotensin receptor binding	ISO	J:164563
Molecular Function	GO:0035612	AP-2 adaptor complex binding	ISO	J:155856
Molecular Function	GO:1990763	arrestin family protein binding	ISO	J:164563
Molecular Function	GO:1990763	arrestin family protein binding	ISO	J:155856
Molecular Function	GO:0035615	clathrin adaptor activity	ISO	J:155856
Molecular Function	GO:0030276	clathrin binding	ISO	J:155856
Molecular Function	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP	J:160042
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0031762	follicle-stimulating hormone receptor binding	ISO	J:155856
Molecular Function	GO:0001664	G protein-coupled receptor binding	IBA	J:265628
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	IDA	J:160042
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0051219	phosphoprotein binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:248230
Molecular Function	GO:0005515	protein binding	IPI	J:72781
Molecular Function	GO:0005515	protein binding	IPI	J:72781
Molecular Function	GO:0045309	protein phosphorylated amino acid binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:155856
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0031896	V2 vasopressin receptor binding	ISO	J:155856
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:160042
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5632657
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:67546
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0031143	pseudopodium	IDA	J:85273
Biological Process	GO:0006897	endocytosis	ISO	J:155856
Biological Process	GO:0042699	follicle-stimulating hormone signaling pathway	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:164563
Biological Process	GO:0002031	G protein-coupled receptor internalization	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:160042
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	IMP	J:245299
Biological Process	GO:0045746	negative regulation of Notch signaling pathway	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0007602	phototransduction	IMP	J:130998
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:160042
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0035066	positive regulation of histone acetylation	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:160042
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	IMP	J:160042
Biological Process	GO:0032092	positive regulation of protein binding	IMP	J:160042
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:164563
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:155856
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction	ISO	J:164563
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0042981	regulation of apoptotic process	IMP	J:160042
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:67546
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:44953
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0043149	stress fiber assembly	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IMP	J:245299
Biological Process	GO:0007601	visual perception	IBA	J:265628