GO Annotations Graph

• Symbol: Arrb2
• Name: arrestin, beta 2
• ID: MGI:99474

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:155856
Molecular Function	GO:0031691	alpha-1A adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031692	alpha-1B adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0031701	angiotensin receptor binding	ISO	J:164563
Molecular Function	GO:0031701	angiotensin receptor binding	IBA	J:265628
Molecular Function	GO:1990763	arrestin family protein binding	ISO	J:155856
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0031762	follicle-stimulating hormone receptor binding	ISO	J:155856
Molecular Function	GO:0001664	G protein-coupled receptor binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0051019	mitogen-activated protein kinase binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0031859	platelet activating factor receptor binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:166091
Molecular Function	GO:0005515	protein binding	IPI	J:248230
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0043422	protein kinase B binding	IPI	J:115106
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	ISO	J:155856
Molecular Function	GO:0031826	type 2A serotonin receptor binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0005905	clathrin-coated pit	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5632657
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0030139	endocytic vesicle	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:243063
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:243063
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:243063
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:243063
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:67546
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Biological Process	GO:0007628	adult walking behavior	IMP	J:115106
Biological Process	GO:0060326	cell chemotaxis	ISO	J:164563
Biological Process	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	ISO	J:155856
Biological Process	GO:0002032	desensitization of G protein-coupled receptor signaling pathway by arrestin	ISO	J:164563
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0006897	endocytosis	ISO	J:155856
Biological Process	GO:0042699	follicle-stimulating hormone signaling pathway	ISO	J:155856
Biological Process	GO:0002031	G protein-coupled receptor internalization	ISO	J:164563
Biological Process	GO:0002031	G protein-coupled receptor internalization	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:243063
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:243063
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0034260	negative regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:112607
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:112607
Biological Process	GO:0032715	negative regulation of interleukin-6 production	IMP	J:112607
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:233559
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0031397	negative regulation of protein ubiquitination	ISO	J:155856
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:155856
Biological Process	GO:0009968	negative regulation of signal transduction	IEA	J:60000
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	IMP	J:112607
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:112607
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:2000727	positive regulation of cardiac muscle cell differentiation	IDA	J:233559
Biological Process	GO:0032967	positive regulation of collagen biosynthetic process	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:1904037	positive regulation of epithelial cell apoptotic process	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:233559
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0045860	positive regulation of protein kinase activity	IC	J:233559
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:155856
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:115106
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:233559
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:155856
Biological Process	GO:0032226	positive regulation of synaptic transmission, dopaminergic	IMP	J:115106
Biological Process	GO:0098926	postsynaptic signal transduction	IMP	J:243063
Biological Process	GO:0098926	postsynaptic signal transduction	IDA	J:243063
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:59162
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:66098
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	IMP	J:67546
Biological Process	GO:0001932	regulation of protein phosphorylation	IGI	J:105642
Biological Process	GO:0001932	regulation of protein phosphorylation	IDA	J:105642
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0006366	transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563