GO Annotations Graph

• Symbol: Chuk
• Name: conserved helix-loop-helix ubiquitous kinase
• ID: MGI:99484

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0008384	IkappaB kinase activity	ISO	J:155856
Molecular Function	GO:0008384	IkappaB kinase activity	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:197514
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:106690
Molecular Function	GO:0005515	protein binding	IPI	J:163158
Molecular Function	GO:0005515	protein binding	IPI	J:131457
Molecular Function	GO:0005515	protein binding	IPI	J:170302
Molecular Function	GO:0005515	protein binding	IPI	J:107628
Molecular Function	GO:0005515	protein binding	IPI	J:173147
Molecular Function	GO:0005515	protein binding	IPI	J:204662
Molecular Function	GO:0005515	protein binding	IPI	J:248213
Molecular Function	GO:0005515	protein binding	IPI	J:182492
Molecular Function	GO:0005515	protein binding	IPI	J:160362
Molecular Function	GO:0005515	protein binding	IPI	J:116077
Molecular Function	GO:0005515	protein binding	IPI	J:181952
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:98564
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:205449
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:1990459	transferrin receptor binding	ISO	J:164563
Cellular Component	GO:0035631	CD40 receptor complex	IDA	J:161997
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	TAS	J:51176
Cellular Component	GO:0009898	cytoplasmic side of plasma membrane	IDA	J:161997
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0008385	IkappaB kinase complex	ISO	J:155856
Cellular Component	GO:0008385	IkappaB kinase complex	IBA	J:265628
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0071276	cellular response to cadmium ion	ISO	J:164563
Biological Process	GO:0034614	cellular response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0098586	cellular response to virus	IMP	J:213232
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0051607	defense response to virus	IMP	J:213232
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IGI	J:90978
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	IMP	J:90978
Biological Process	GO:0007252	I-kappaB phosphorylation	TAS	J:51176
Biological Process	GO:0007595	lactation	IMP	J:90978
Biological Process	GO:0007595	lactation	IGI	J:90978
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:90978
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:90978
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:90978
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IGI	J:90978
Biological Process	GO:0002011	morphogenesis of an epithelial sheet	IMP	J:90053
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0038061	NIK/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:90053
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:95156
Biological Process	GO:0030316	osteoclast differentiation	IMP	J:95156
Biological Process	GO:0030316	osteoclast differentiation	IGI	J:95156
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI	J:90978
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP	J:90978
Biological Process	GO:0032727	positive regulation of interferon-alpha production	IMP	J:213232
Biological Process	GO:0032727	positive regulation of interferon-alpha production	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IBA	J:265628
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:275558
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0061847	response to cholecystokinin	ISO	J:155856
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0035994	response to muscle stretch	IMP	J:163557
Biological Process	GO:0010033	response to organic substance	ISO	J:155856
Biological Process	GO:0007266	Rho protein signal transduction	ISO	J:155856
Biological Process	GO:0051146	striated muscle cell differentiation	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IBA	J:265628