GO Annotations Graph

• Symbol: Fgb
• Name: fibrinogen beta chain
• ID: MGI:99501

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265604
Molecular Function	GO:0005201	extracellular matrix structural constituent	RCA	J:265607
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:164563
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Molecular Function	GO:0005198	structural molecule activity	ISO	J:164563
Cellular Component	GO:0072562	blood microparticle	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	IDA	J:118491
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265607
Cellular Component	GO:0062023	collagen-containing extracellular matrix	HDA	J:265604
Cellular Component	GO:0062023	collagen-containing extracellular matrix	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005577	fibrinogen complex	ISO	J:164563
Cellular Component	GO:0005577	fibrinogen complex	ISO	J:164563
Cellular Component	GO:0031091	platelet alpha granule	ISO	J:164563
Cellular Component	GO:0045202	synapse	EXP	J:263376
Cellular Component	GO:0045202	synapse	IDA	J:263376
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0007596	blood coagulation	IEA	J:72247
Biological Process	GO:0007596	blood coagulation	IEA	J:60000
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	ISO	J:164563
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	IBA	J:265628
Biological Process	GO:0007160	cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007160	cell-matrix adhesion	IBA	J:265628
Biological Process	GO:0042730	fibrinolysis	ISO	J:164563
Biological Process	GO:0007599	hemostasis	IEA	J:60000
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0043152	induction of bacterial agglutination	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0031639	plasminogen activation	ISO	J:164563
Biological Process	GO:0030168	platelet activation	IEA	J:72247
Biological Process	GO:0070527	platelet aggregation	ISO	J:164563
Biological Process	GO:0070527	platelet aggregation	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0045921	positive regulation of exocytosis	ISO	J:164563
Biological Process	GO:0034116	positive regulation of heterotypic cell-cell adhesion	ISO	J:164563
Biological Process	GO:0090277	positive regulation of peptide hormone secretion	ISO	J:164563
Biological Process	GO:0050714	positive regulation of protein secretion	ISO	J:164563
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:164563
Biological Process	GO:0051258	protein polymerization	ISO	J:164563
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0051592	response to calcium ion	ISO	J:164563