GO Annotations Graph

• Symbol: Ptpn11
• Name: protein tyrosine phosphatase, non-receptor type 11
• ID: MGI:99511

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0045296	cadherin binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:231275
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:155856
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0031748	D1 dopamine receptor binding	ISO	J:155856
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:164563
Molecular Function	GO:0005158	insulin receptor binding	ISO	J:155856
Molecular Function	GO:0043560	insulin receptor substrate binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IBA	J:265628
Molecular Function	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	IMP	J:91609
Molecular Function	GO:0051428	peptide hormone receptor binding	IPI	J:94738
Molecular Function	GO:0016791	phosphatase activity	IEA	J:72247
Molecular Function	GO:0043274	phospholipase binding	ISO	J:155856
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	ISO	J:164563
Molecular Function	GO:0004721	phosphoprotein phosphatase activity	IMP	J:91609
Molecular Function	GO:0001784	phosphotyrosine residue binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:126125
Molecular Function	GO:0005515	protein binding	IPI	J:161854
Molecular Function	GO:0005515	protein binding	IPI	J:202593
Molecular Function	GO:0005515	protein binding	IPI	J:186456
Molecular Function	GO:0005515	protein binding	IPI	J:206901
Molecular Function	GO:0005515	protein binding	IPI	J:200354
Molecular Function	GO:0005515	protein binding	IPI	J:201266
Molecular Function	GO:0005515	protein binding	IPI	J:186638
Molecular Function	GO:0005515	protein binding	IPI	J:176469
Molecular Function	GO:0005515	protein binding	IPI	J:159097
Molecular Function	GO:0005515	protein binding	IPI	J:200346
Molecular Function	GO:0005515	protein binding	IPI	J:171253
Molecular Function	GO:0005515	protein binding	IPI	J:201126
Molecular Function	GO:0005515	protein binding	IPI	J:200361
Molecular Function	GO:0005515	protein binding	IPI	J:200332
Molecular Function	GO:0005515	protein binding	IPI	J:314643
Molecular Function	GO:0005515	protein binding	IPI	J:83953
Molecular Function	GO:0005515	protein binding	IPI	J:91609
Molecular Function	GO:0005515	protein binding	IPI	J:145327
Molecular Function	GO:0005515	protein binding	IPI	J:51814
Molecular Function	GO:0005515	protein binding	IPI	J:94873
Molecular Function	GO:0005515	protein binding	IPI	J:126196
Molecular Function	GO:0005515	protein binding	IPI	J:78670
Molecular Function	GO:0005515	protein binding	IPI	J:75835
Molecular Function	GO:0005515	protein binding	IPI	J:94873
Molecular Function	GO:0005515	protein binding	IPI	J:84084
Molecular Function	GO:0005515	protein binding	IPI	J:84951
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0019901	protein kinase binding	IPI	J:126125
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:1990782	protein tyrosine kinase binding	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:155856
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	ISO	J:164563
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	IDA	J:140959
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IPI	J:112094
Molecular Function	GO:0030971	receptor tyrosine kinase binding	ISO	J:155856
Molecular Function	GO:0030971	receptor tyrosine kinase binding	IBA	J:265628
Molecular Function	GO:0030159	signaling receptor complex adaptor activity	ISO	J:164563
Cellular Component	GO:0030054	cell junction	ISS	J:83590
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671739
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-2671740
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-418862
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-914067
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9604980
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9606789
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645128
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645133
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9645136
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9674973
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9680646
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682158
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9682182
Cellular Component	GO:0016020	membrane	ISS	J:83590
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0001725	stress fiber	ISS	J:83590
Biological Process	GO:0036302	atrioventricular canal development	ISO	J:164563
Biological Process	GO:0007409	axonogenesis	IMP	J:80747
Biological Process	GO:0060020	Bergmann glial cell differentiation	IGI	J:205567
Biological Process	GO:0060020	Bergmann glial cell differentiation	IMP	J:205567
Biological Process	GO:0007420	brain development	ISO	J:164563
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0071260	cellular response to mechanical stimulus	ISO	J:155856
Biological Process	GO:0021697	cerebellar cortex formation	IGI	J:205567
Biological Process	GO:0021697	cerebellar cortex formation	IMP	J:205567
Biological Process	GO:0016311	dephosphorylation	IEA	J:72247
Biological Process	GO:0000077	DNA damage checkpoint signaling	IMP	J:86382
Biological Process	GO:0048013	ephrin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:60750
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0038127	ERBB signaling pathway	ISO	J:164563
Biological Process	GO:0060325	face morphogenesis	ISO	J:164563
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048806	genitalia development	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:94738
Biological Process	GO:0007507	heart development	ISO	J:164563
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IGI	J:214268
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	IMP	J:214268
Biological Process	GO:0042445	hormone metabolic process	IMP	J:94738
Biological Process	GO:0009755	hormone-mediated signaling pathway	IDA	J:94738
Biological Process	GO:0048839	inner ear development	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:197924
Biological Process	GO:0061582	intestinal epithelial cell migration	IMP	J:214268
Biological Process	GO:0006629	lipid metabolic process	IMP	J:94738
Biological Process	GO:0035855	megakaryocyte development	IMP	J:197924
Biological Process	GO:0032528	microvillus organization	IMP	J:214268
Biological Process	GO:0035264	multicellular organism growth	IMP	J:214268
Biological Process	GO:0035264	multicellular organism growth	IMP	J:94738
Biological Process	GO:0048609	multicellular organismal reproductive process	IMP	J:94738
Biological Process	GO:0033629	negative regulation of cell adhesion mediated by integrin	IMP	J:197924
Biological Process	GO:0032331	negative regulation of chondrocyte differentiation	IMP	J:287059
Biological Process	GO:0051463	negative regulation of cortisol secretion	IMP	J:94738
Biological Process	GO:0060125	negative regulation of growth hormone secretion	IMP	J:94738
Biological Process	GO:0046888	negative regulation of hormone secretion	IMP	J:94738
Biological Process	GO:0046676	negative regulation of insulin secretion	IMP	J:94738
Biological Process	GO:0032480	negative regulation of type I interferon production	ISO	J:164563
Biological Process	GO:0048011	neurotrophin TRK receptor signaling pathway	IMP	J:80747
Biological Process	GO:0035265	organ growth	IMP	J:94738
Biological Process	GO:0035335	peptidyl-tyrosine dephosphorylation	ISO	J:164563
Biological Process	GO:0030220	platelet formation	IGI	J:197924
Biological Process	GO:0030220	platelet formation	IGI	J:197924
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IGI	J:140959
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	J:140959
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IGI	J:205567
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0046887	positive regulation of hormone secretion	IMP	J:94738
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032728	positive regulation of interferon-beta production	IMP	J:126125
Biological Process	GO:0032755	positive regulation of interleukin-6 production	IGI	J:126125
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IGI	J:140959
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	IGI	J:140959
Biological Process	GO:0045778	positive regulation of ossification	IMP	J:287059
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0009967	positive regulation of signal transduction	IMP	J:94738
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	IGI	J:126125
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:164563
Biological Process	GO:0006470	protein dephosphorylation	ISO	J:155856
Biological Process	GO:0006470	protein dephosphorylation	IBA	J:265628
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	ISO	J:164563
Biological Process	GO:0043408	regulation of MAPK cascade	IMP	J:91609
Biological Process	GO:0043408	regulation of MAPK cascade	IMP	J:86382
Biological Process	GO:0046825	regulation of protein export from nucleus	IMP	J:86382
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IMP	J:94738
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:94738