GO Annotations Graph

• Symbol: Pde4d
• Name: phosphodiesterase 4D, cAMP specific
• ID: MGI:99555

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:175643
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	J:72247
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IDA	J:58116
Molecular Function	GO:0051117	ATPase binding	IPI	J:188825
Molecular Function	GO:0051117	ATPase binding	ISO	J:164563
Molecular Function	GO:0051117	ATPase binding	IBA	J:265628
Molecular Function	GO:0031698	beta-2 adrenergic receptor binding	ISO	J:155856
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0004112	cyclic-nucleotide phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:1901363	heterocyclic compound binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:131299
Molecular Function	GO:0005515	protein binding	IPI	J:148806
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:115187
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:175643
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Molecular Function	GO:0044325	transmembrane transporter binding	IBA	J:265628
Cellular Component	GO:0034704	calcium channel complex	IDA	J:115187
Cellular Component	GO:0034704	calcium channel complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:155856
Cellular Component	GO:0005813	centrosome	IDA	J:143215
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0030016	myofibril	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0034705	potassium channel complex	IDA	J:148806
Cellular Component	GO:0034705	potassium channel complex	IPI	J:148806
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IDA	J:175643
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:155856
Biological Process	GO:0019933	cAMP-mediated signaling	IMP	J:58116
Biological Process	GO:0019933	cAMP-mediated signaling	IDA	J:58116
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:164563
Biological Process	GO:0071320	cellular response to cAMP	ISO	J:148806
Biological Process	GO:0071320	cellular response to cAMP	IDA	J:148806
Biological Process	GO:0071872	cellular response to epinephrine stimulus	IMP	J:115187
Biological Process	GO:0071872	cellular response to epinephrine stimulus	ISO	J:164563
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	IMP	J:58116
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	IMP	J:58116
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:94853
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:94853
Biological Process	GO:0061028	establishment of endothelial barrier	ISO	J:155856
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0035264	multicellular organism growth	IMP	J:58116
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	ISO	J:164563
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	IBA	J:265628
Biological Process	GO:0045822	negative regulation of heart contraction	IMP	J:188825
Biological Process	GO:0033137	negative regulation of peptidyl-serine phosphorylation	IMP	J:115187
Biological Process	GO:1901898	negative regulation of relaxation of cardiac muscle	IMP	J:175643
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:94853
Biological Process	GO:1990266	neutrophil migration	IMP	J:94853
Biological Process	GO:0001542	ovulation from ovarian follicle	IMP	J:58116
Biological Process	GO:0001542	ovulation from ovarian follicle	IMP	J:58116
Biological Process	GO:0022409	positive regulation of cell-cell adhesion	ISO	J:155856
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032754	positive regulation of interleukin-5 production	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	ISO	J:155856
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0043949	regulation of cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:175643
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:188825
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	ISO	J:155856
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IBA	J:265628
Biological Process	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction	IC	J:115187
Biological Process	GO:0008277	regulation of G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0002027	regulation of heart rate	IMP	J:115187
Biological Process	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:115187
Biological Process	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	IMP	J:115187
Biological Process	GO:0010469	regulation of signaling receptor activity	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0006939	smooth muscle contraction	IMP	J:85992
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563