GO Annotations Graph

• Symbol: Pde4b
• Name: phosphodiesterase 4B, cAMP specific
• ID: MGI:99557

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:175643
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISS	J:54338
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0043015	gamma-tubulin binding	IDA	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0005515	protein binding	IPI	J:143215
Molecular Function	GO:0044325	transmembrane transporter binding	IPI	J:175643
Molecular Function	GO:0044325	transmembrane transporter binding	IBA	J:265628
Cellular Component	GO:0071944	cell periphery	IDA	J:141092
Cellular Component	GO:0005813	centrosome	IDA	J:143215
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:210072
Cellular Component	GO:0043197	dendritic spine	IDA	J:143215
Cellular Component	GO:0060076	excitatory synapse	IDA	J:143215
Cellular Component	GO:0000930	gamma-tubulin complex	IDA	J:143215
Cellular Component	GO:0016020	membrane	IDA	J:210072
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	IDA	J:143215
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:143215
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IDA	J:175643
Cellular Component	GO:0030018	Z disc	IMP	J:175643
Biological Process	GO:0071872	cellular response to epinephrine stimulus	IMP	J:175643
Biological Process	GO:0071222	cellular response to lipopolysaccharide	IMP	J:94853
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:65927
Biological Process	GO:0050900	leukocyte migration	IMP	J:94853
Biological Process	GO:0140199	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	IMP	J:175643
Biological Process	GO:1901898	negative regulation of relaxation of cardiac muscle	IMP	J:175643
Biological Process	GO:0030593	neutrophil chemotaxis	IMP	J:94853
Biological Process	GO:0001780	neutrophil homeostasis	IMP	J:94853
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0086004	regulation of cardiac muscle cell contraction	IMP	J:175643
Biological Process	GO:1901841	regulation of high voltage-gated calcium channel activity	IMP	J:175643
Biological Process	GO:0009408	response to heat	ISO	J:155856
Biological Process	GO:0050852	T cell receptor signaling pathway	ISO	J:164563