GO Annotations Graph

• Symbol: Pde4a
• Name: phosphodiesterase 4A, cAMP specific
• ID: MGI:99558

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:175643
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:164563
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IDA	J:65927
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISO	J:155856
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	IBA	J:265628
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	ISS	J:54338
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	IEA	J:72247
Molecular Function	GO:0030552	cAMP binding	ISO	J:164563
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:150514
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:210072
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:155856
Cellular Component	GO:0019898	extrinsic component of membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IDA	J:210072
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Biological Process	GO:0006198	cAMP catabolic process	ISO	J:155856
Biological Process	GO:0006198	cAMP catabolic process	ISO	J:164563
Biological Process	GO:0006198	cAMP catabolic process	IDA	J:65927
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	IDA	J:65927
Biological Process	GO:0050804	modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:141092
Biological Process	GO:0010738	regulation of protein kinase A signaling	IMP	J:141092
Biological Process	GO:0007608	sensory perception of smell	IGI	J:150514
Biological Process	GO:0007165	signal transduction	IEA	J:72247