GO Annotations Graph

• Symbol: Aldh2
• Name: aldehyde dehydrogenase 2, mitochondrial
• ID: MGI:99600

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ISO	J:155856
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	ISO	J:164563
Molecular Function	GO:0004029	aldehyde dehydrogenase (NAD+) activity	IBA	J:265628
Molecular Function	GO:0106435	carboxylesterase activity	ISO	J:164563
Molecular Function	GO:0043878	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity	IEA	J:72245
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0051287	NAD binding	ISS	J:240299
Molecular Function	GO:0070404	NADH binding	ISO	J:155856
Molecular Function	GO:0018547	nitroglycerin reductase activity	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:174774
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Biological Process	GO:0006117	acetaldehyde metabolic process	ISO	J:155856
Biological Process	GO:0046185	aldehyde catabolic process	ISO	J:164563
Biological Process	GO:0048149	behavioral response to ethanol	ISO	J:155856
Biological Process	GO:0110095	cellular detoxification of aldehyde	ISO	J:155856
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1903179	regulation of dopamine biosynthetic process	IMP	J:314649
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:155856
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:1905627	regulation of serotonin biosynthetic process	IMP	J:314649
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856