GO Annotations Graph

• Symbol: Acan
• Name: aggrecan
• ID: MGI:99602

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0030246	carbohydrate binding	IEA	J:60000
Molecular Function	GO:0005540	hyaluronic acid binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:177177
Molecular Function	GO:0005515	protein binding	IPI	J:102464
Cellular Component	GO:0005604	basement membrane	IDA	J:102464
Cellular Component	GO:0031012	extracellular matrix	IDA	J:128547
Cellular Component	GO:0031012	extracellular matrix	IDA	J:86321
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	HDA	J:221550
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:263381
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:263381
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:263381
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263381
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263381
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:263381
Cellular Component	GO:0043005	neuron projection	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0072534	perineuronal net	ISO	J:155856
Cellular Component	GO:0072534	perineuronal net	IBA	J:265628
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0098966	perisynaptic extracellular matrix	IDA	J:263381
Cellular Component	GO:0045202	synapse	IBA	J:265628
Biological Process	GO:0001502	cartilage condensation	IMP	J:83918
Biological Process	GO:0007155	cell adhesion	IEA	J:72247
Biological Process	GO:0002063	chondrocyte development	IMP	J:48562
Biological Process	GO:0030199	collagen fibril organization	IMP	J:83918
Biological Process	GO:0010001	glial cell differentiation	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:222159
Biological Process	GO:0030336	negative regulation of cell migration	ISO	J:155856
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IBA	J:265628
Biological Process	GO:0030166	proteoglycan biosynthetic process	IMP	J:83918