GO Annotations Graph

• Symbol: Cntfr
• Name: ciliary neurotrophic factor receptor
• ID: MGI:99605

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	ISO	J:164563
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	ISO	J:155856
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	IGI	J:29357
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	IGI	J:29357
Molecular Function	GO:0019955	cytokine binding	ISO	J:164563
Molecular Function	GO:0019955	cytokine binding	ISO	J:155856
Molecular Function	GO:0019955	cytokine binding	IBA	J:265628
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:89246
Molecular Function	GO:0005102	signaling receptor binding	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	ISO	J:164563
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	IBA	J:265628
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	ISO	J:164563
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0003360	brainstem development	IMP	J:29357
Biological Process	GO:0003360	brainstem development	IMP	J:29357
Biological Process	GO:0003360	brainstem development	IMP	J:29357
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IGI	J:29357
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	IGI	J:29357
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:70506
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:137159
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:137159
Biological Process	GO:2000672	negative regulation of motor neuron apoptotic process	IMP	J:70506
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:89246
Biological Process	GO:0007548	sex differentiation	IMP	J:59710
Biological Process	GO:0060538	skeletal muscle organ development	IMP	J:59710
Biological Process	GO:0001967	suckling behavior	IMP	J:29357