GO Annotations Graph

• Symbol: Abca2
• Name: ATP-binding cassette, sub-family A member 2
• ID: MGI:99606

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0140359	ABC-type transporter activity	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0099038	ceramide floppase activity	ISO	J:164563
Molecular Function	GO:0061135	endopeptidase regulator activity	ISO	J:164563
Molecular Function	GO:0005319	lipid transporter activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	IBA	J:265628
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:155856
Cellular Component	GO:0005765	lysosomal membrane	IDA	J:297523
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:164563
Cellular Component	GO:0005765	lysosomal membrane	ISO	J:73065
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0005815	microtubule organizing center	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0032289	central nervous system myelin formation	IMP	J:117673
Biological Process	GO:0032289	central nervous system myelin formation	ISO	J:155856
Biological Process	GO:0099040	ceramide translocation	ISO	J:164563
Biological Process	GO:0008203	cholesterol metabolic process	ISO	J:73065
Biological Process	GO:0001573	ganglioside metabolic process	IMP	J:123521
Biological Process	GO:0006687	glycosphingolipid metabolic process	IMP	J:123521
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	ISO	J:164563
Biological Process	GO:0006869	lipid transport	IBA	J:265628
Biological Process	GO:0007626	locomotory behavior	IMP	J:117673
Biological Process	GO:0090370	negative regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0032384	negative regulation of intracellular cholesterol transport	ISO	J:164563
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ISO	J:164563
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	IDA	J:180725
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ISO	J:155856
Biological Process	GO:0071072	negative regulation of phospholipid biosynthetic process	ISO	J:164563
Biological Process	GO:0071072	negative regulation of phospholipid biosynthetic process	ISO	J:155856
Biological Process	GO:1905601	negative regulation of receptor-mediated endocytosis involved in cholesterol transport	ISO	J:164563
Biological Process	GO:0090155	negative regulation of sphingolipid biosynthetic process	ISO	J:164563
Biological Process	GO:0090155	negative regulation of sphingolipid biosynthetic process	ISO	J:155856
Biological Process	GO:0045939	negative regulation of steroid metabolic process	ISO	J:155856
Biological Process	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	ISO	J:164563
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	ISO	J:164563
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:155856
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ISO	J:164563
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	ISO	J:164563
Biological Process	GO:0032383	regulation of intracellular cholesterol transport	ISO	J:164563
Biological Process	GO:0032383	regulation of intracellular cholesterol transport	IMP	J:297317
Biological Process	GO:1901873	regulation of post-translational protein modification	ISO	J:164563
Biological Process	GO:0060049	regulation of protein glycosylation	IMP	J:277862
Biological Process	GO:1904375	regulation of protein localization to cell periphery	IMP	J:277862
Biological Process	GO:2000008	regulation of protein localization to cell surface	IMP	J:277862
Biological Process	GO:0019218	regulation of steroid metabolic process	ISO	J:164563
Biological Process	GO:0006684	sphingomyelin metabolic process	IMP	J:123521
Biological Process	GO:0046512	sphingosine biosynthetic process	ISO	J:164563
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247