GO Annotations Graph

• Symbol: Ephb2
• Name: Eph receptor B2
• ID: MGI:99611

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001540	amyloid-beta binding	IPI	J:167228
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0008046	axon guidance receptor activity	IDA	J:71036
Molecular Function	GO:0005003	ephrin receptor activity	IDA	J:73356
Molecular Function	GO:0042802	identical protein binding	IPI	J:200429
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:116386
Molecular Function	GO:0005515	protein binding	IPI	J:248221
Molecular Function	GO:0005515	protein binding	IPI	J:51893
Molecular Function	GO:0005515	protein binding	IPI	J:266463
Molecular Function	GO:0005515	protein binding	IPI	J:200429
Molecular Function	GO:0005515	protein binding	IPI	J:167228
Molecular Function	GO:0005515	protein binding	IPI	J:62565
Molecular Function	GO:0005515	protein binding	IPI	J:167914
Molecular Function	GO:0005515	protein binding	IPI	J:51893
Molecular Function	GO:0005515	protein binding	IPI	J:85573
Molecular Function	GO:0005515	protein binding	IPI	J:73356
Molecular Function	GO:0005515	protein binding	IPI	J:73508
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IMP	J:167228
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:51893
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:167228
Molecular Function	GO:0038023	signaling receptor activity	IDA	J:73356
Molecular Function	GO:0005102	signaling receptor binding	IPI	J:73508
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	J:72245
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	IDA	J:167914
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	IBA	J:265628
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	TAS	J:71036
Cellular Component	GO:0030424	axon	IDA	J:34200
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:87071
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:138754
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:116171
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:116171
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:155856
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:267455
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:267455
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IPI	J:267455
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IDA	J:267455
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	IPI	J:267455
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:85573
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:34200
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928599
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928605
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928613
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928626
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928630
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928635
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928643
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-4093335
Cellular Component	GO:0005886	plasma membrane	TAS	J:71036
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IEP	J:138754
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IPI	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IPI	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IPI	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IPI	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:267455
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IEP	J:138754
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:138754
Cellular Component	GO:0045202	synapse	NAS	J:51893
Biological Process	GO:0001525	angiogenesis	IMP	J:53085
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:91491
Biological Process	GO:0007411	axon guidance	IMP	J:62565
Biological Process	GO:0007411	axon guidance	IMP	J:37095
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007411	axon guidance	IDA	J:71036
Biological Process	GO:0007413	axonal fasciculation	IMP	J:37095
Biological Process	GO:0007409	axonogenesis	IDA	J:85573
Biological Process	GO:0042113	B cell activation	ISO	J:164563
Biological Process	GO:0048593	camera-type eye morphogenesis	IMP	J:85573
Biological Process	GO:0000902	cell morphogenesis	IGI	J:128355
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	IMP	J:85573
Biological Process	GO:0071679	commissural neuron axon guidance	IMP	J:34200
Biological Process	GO:0022038	corpus callosum development	IMP	J:37095
Biological Process	GO:0060996	dendritic spine development	IMP	J:87071
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:87071
Biological Process	GO:0060997	dendritic spine morphogenesis	IDA	J:120748
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:167914
Biological Process	GO:0048013	ephrin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:120748
Biological Process	GO:0048013	ephrin receptor signaling pathway	IDA	J:128355
Biological Process	GO:0021934	hindbrain tangential cell migration	ISO	J:155856
Biological Process	GO:0042472	inner ear morphogenesis	IMP	J:62565
Biological Process	GO:0007612	learning	IMP	J:73508
Biological Process	GO:0007611	learning or memory	IGI	J:167228
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0050771	negative regulation of axonogenesis	IDA	J:85573
Biological Process	GO:0007162	negative regulation of cell adhesion	ISO	J:164563
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	ISO	J:155856
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IDA	J:242479
Biological Process	GO:1904782	negative regulation of NMDA glutamate receptor activity	IMP	J:167228
Biological Process	GO:0006469	negative regulation of protein kinase activity	IDA	J:242479
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IDA	J:242479
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	IDA	J:242479
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0106028	neuron projection retraction	IDA	J:242479
Biological Process	GO:0021631	optic nerve morphogenesis	IMP	J:85573
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:167914
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IMP	J:167228
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:128355
Biological Process	GO:0016310	phosphorylation	IDA	J:51893
Biological Process	GO:0030890	positive regulation of B cell proliferation	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0002639	positive regulation of immunoglobulin production	ISO	J:164563
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	IMP	J:73504
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	IMP	J:167228
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	IMP	J:167228
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	ISO	J:155856
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	ISO	J:155856
Biological Process	GO:0051965	positive regulation of synapse assembly	IDA	J:167914
Biological Process	GO:0051965	positive regulation of synapse assembly	IMP	J:87071
Biological Process	GO:0051965	positive regulation of synapse assembly	ISO	J:155856
Biological Process	GO:0031915	positive regulation of synaptic plasticity	IGI	J:167228
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0097104	postsynaptic membrane assembly	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:85573
Biological Process	GO:2000785	regulation of autophagosome assembly	ISO	J:164563
Biological Process	GO:0050770	regulation of axonogenesis	IDA	J:88877
Biological Process	GO:2000822	regulation of behavioral fear response	ISO	J:155856
Biological Process	GO:0030193	regulation of blood coagulation	ISO	J:164563
Biological Process	GO:0050878	regulation of body fluid levels	IMP	J:62565
Biological Process	GO:0051489	regulation of filopodium assembly	ISO	J:155856
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	IMP	J:73508
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	ISO	J:155856
Biological Process	GO:0051963	regulation of synapse assembly	IDA	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IDA	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	EXP	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IDA	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IMP	J:116171
Biological Process	GO:0051963	regulation of synapse assembly	IDA	J:116171
Biological Process	GO:2000316	regulation of T-helper 17 type immune response	ISO	J:155856
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IDA	J:85573
Biological Process	GO:0060021	roof of mouth development	IMP	J:37095
Biological Process	GO:0120192	tight junction assembly	ISO	J:155856
Biological Process	GO:0099557	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IMP	J:238466
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	J:88877
Biological Process	GO:0001655	urogenital system development	IMP	J:91491
Biological Process	GO:0110077	vesicle-mediated intercellular transport	ISO	J:155856