GO Annotations Graph

• Symbol: Ryr1
• Name: ryanodine receptor 1, skeletal muscle
• ID: MGI:99659

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005262	calcium channel activity	IMP	J:127629
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0048763	calcium-induced calcium release activity	ISO	J:164563
Molecular Function	GO:0048763	calcium-induced calcium release activity	IBA	J:265628
Molecular Function	GO:0005516	calmodulin binding	IEA	J:60000
Molecular Function	GO:0019899	enzyme binding	IPI	J:146474
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0002020	protease binding	IPI	J:140035
Molecular Function	GO:0005515	protein binding	IPI	J:132211
Molecular Function	GO:0005515	protein binding	IPI	J:114108
Molecular Function	GO:0005515	protein binding	IPI	J:187976
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ISO	J:155856
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	ISO	J:164563
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IMP	J:26886
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	IBA	J:265628
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:127629
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IDA	J:87930
Cellular Component	GO:0034704	calcium channel complex	IBA	J:265628
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:155856
Cellular Component	GO:0031674	I band	ISO	J:164563
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0030314	junctional membrane complex	IDA	J:56913
Cellular Component	GO:0016020	membrane	IDA	J:84111
Cellular Component	GO:0016020	membrane	IDA	J:22418
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:140035
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Cellular Component	GO:0042383	sarcolemma	IBA	J:265628
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:37052
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:22418
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:96149
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:72636
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:87930
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	ISO	J:155856
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:127629
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IBA	J:265628
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:87932
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005790	smooth endoplasmic reticulum	IDA	J:202429
Cellular Component	GO:0030315	T-tubule	IDA	J:201107
Cellular Component	GO:0030315	T-tubule	IDA	J:96149
Cellular Component	GO:0030315	T-tubule	IDA	J:37052
Cellular Component	GO:0030315	T-tubule	IDA	J:182140
Cellular Component	GO:0014802	terminal cisterna	ISO	J:155856
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:60000
Biological Process	GO:0070588	calcium ion transmembrane transport	IEA	J:72247
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	IDA	J:87930
Biological Process	GO:0071318	cellular response to ATP	ISO	J:155856
Biological Process	GO:0071313	cellular response to caffeine	IMP	J:26886
Biological Process	GO:0071313	cellular response to caffeine	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0006936	muscle contraction	IMP	J:18895
Biological Process	GO:0006936	muscle contraction	IDA	J:87930
Biological Process	GO:0006936	muscle contraction	IMP	J:84111
Biological Process	GO:0043931	ossification involved in bone maturation	IMP	J:127629
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:127629
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0006937	regulation of muscle contraction	TAS	J:72636
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:155856
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IMP	J:84111
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO	J:155856
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP	J:127629
Biological Process	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA	J:265628
Biological Process	GO:0031000	response to caffeine	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	ISO	J:155856
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:127629
Biological Process	GO:0043588	skin development	IMP	J:127629
Biological Process	GO:0006941	striated muscle contraction	IBA	J:265628
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247