GO Annotations Graph

• Symbol: Pola1
• Name: polymerase (DNA directed), alpha 1
• ID: MGI:99660

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003688	DNA replication origin binding	IBA	J:265628
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	ISO	J:155856
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	ISO	J:164563
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	IBA	J:265628
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	IDA	J:16650
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	IDA	J:47666
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0003676	nucleic acid binding	IEA	J:72247
Molecular Function	GO:0000166	nucleotide binding	ISO	J:164563
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:113778
Molecular Function	GO:0005515	protein binding	IPI	J:113778
Molecular Function	GO:0005515	protein binding	IPI	J:47666
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0017076	purine nucleotide binding	ISO	J:155856
Molecular Function	GO:0019103	pyrimidine nucleotide binding	ISO	J:155856
Molecular Function	GO:0003697	single-stranded DNA binding	IBA	J:265628
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	IPI	J:113778
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	ISO	J:164563
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	IDA	J:297455
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	ISO	J:155856
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	IBA	J:265628
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex	IDA	J:47666
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:47666
Biological Process	GO:0071897	DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0006260	DNA replication	ISO	J:164563
Biological Process	GO:0006260	DNA replication	ISO	J:155856
Biological Process	GO:0006260	DNA replication	IDA	J:16650
Biological Process	GO:0006260	DNA replication	IMP	J:17170
Biological Process	GO:0006260	DNA replication	IDA	J:47666
Biological Process	GO:0006270	DNA replication initiation	IDA	J:113778
Biological Process	GO:0006270	DNA replication initiation	ISO	J:164563
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	IDA	J:297455
Biological Process	GO:0006269	DNA replication, synthesis of RNA primer	ISO	J:164563
Biological Process	GO:0006271	DNA strand elongation involved in DNA replication	ISO	J:164563
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	ISO	J:164563
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0006273	lagging strand elongation	ISO	J:164563
Biological Process	GO:0006273	lagging strand elongation	IBA	J:265628
Biological Process	GO:0006272	leading strand elongation	ISO	J:164563
Biological Process	GO:0006272	leading strand elongation	IBA	J:265628
Biological Process	GO:1902975	mitotic DNA replication initiation	IBA	J:265628
Biological Process	GO:0032479	regulation of type I interferon production	ISO	J:164563