GO Annotations Graph

• Symbol: Syt1
• Name: synaptotagmin I
• ID: MGI:99667

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IBA	J:265628
Molecular Function	GO:0005509	calcium ion binding	IDA	J:91437
Molecular Function	GO:0061891	calcium ion sensor activity	IDA	J:174823
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	ISO	J:155856
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IDA	J:235272
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	IBA	J:265628
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	TAS	J:85318
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0048306	calcium-dependent protein binding	IPI	J:99919
Molecular Function	GO:0005516	calmodulin binding	ISO	J:155856
Molecular Function	GO:0030276	clathrin binding	ISO	J:155856
Molecular Function	GO:0030276	clathrin binding	IBA	J:265628
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0050750	low-density lipoprotein particle receptor binding	ISO	J:90197
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ISO	J:155856
Molecular Function	GO:0001786	phosphatidylserine binding	ISO	J:155856
Molecular Function	GO:0001786	phosphatidylserine binding	IBA	J:265628
Molecular Function	GO:0005543	phospholipid binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:146245
Molecular Function	GO:0005515	protein binding	IPI	J:95183
Molecular Function	GO:0005515	protein binding	IPI	J:235086
Molecular Function	GO:0005515	protein binding	IPI	J:232854
Molecular Function	GO:0005515	protein binding	IPI	J:184429
Molecular Function	GO:0005515	protein binding	IPI	J:92516
Molecular Function	GO:0005515	protein binding	IPI	J:114143
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0019905	syntaxin binding	ISO	J:155856
Molecular Function	GO:0019905	syntaxin binding	IBA	J:265628
Molecular Function	GO:0017075	syntaxin-1 binding	IDA	J:138035
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:155856
Molecular Function	GO:0030348	syntaxin-3 binding	ISO	J:155856
Cellular Component	GO:0030424	axon	IDA	J:235258
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0031045	dense core granule	ISO	J:155856
Cellular Component	GO:0031045	dense core granule	IDA	J:136185
Cellular Component	GO:0031045	dense core granule	IBA	J:265628
Cellular Component	GO:0031045	dense core granule	ISO	J:73065
Cellular Component	GO:0060076	excitatory synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:21602
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:89660
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	ISO	J:155856
Cellular Component	GO:0043229	intracellular organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IDA	J:169453
Cellular Component	GO:0043005	neuron projection	IDA	J:89660
Cellular Component	GO:0043005	neuron projection	IDA	J:91437
Cellular Component	GO:0044306	neuron projection terminus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	J:95183
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:91437
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	IDA	J:78421
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008021	synaptic vesicle	ISO	J:155856
Cellular Component	GO:0008021	synaptic vesicle	TAS	J:95183
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:125904
Cellular Component	GO:0008021	synaptic vesicle	IDA	J:104925
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	ISO	J:155856
Cellular Component	GO:0030672	synaptic vesicle membrane	IBA	J:265628
Cellular Component	GO:0030672	synaptic vesicle membrane	IDA	J:90137
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	IBA	J:265628
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	IMP	J:174823
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IEP	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IMP	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	IDA	J:21602
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0071277	cellular response to calcium ion	ISO	J:155856
Biological Process	GO:0071277	cellular response to calcium ion	IBA	J:265628
Biological Process	GO:0005513	detection of calcium ion	ISO	J:155856
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	IDA	J:89486
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	IMP	J:21602
Biological Process	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter	IMP	J:111167
Biological Process	GO:0007269	neurotransmitter secretion	IDA	J:91437
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis	ISO	J:155856
Biological Process	GO:1903235	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	IMP	J:76452
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:164563
Biological Process	GO:0033603	positive regulation of dopamine secretion	ISO	J:155856
Biological Process	GO:0050806	positive regulation of synaptic transmission	IMP	J:21602
Biological Process	GO:0031340	positive regulation of vesicle fusion	ISO	J:155856
Biological Process	GO:0051291	protein heterooligomerization	ISO	J:155856
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	ISO	J:155856
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	IMP	J:126394
Biological Process	GO:0017158	regulation of calcium ion-dependent exocytosis	IBA	J:265628
Biological Process	GO:0014059	regulation of dopamine secretion	IMP	J:235258
Biological Process	GO:0014059	regulation of dopamine secretion	IBA	J:265628
Biological Process	GO:1903305	regulation of regulated secretory pathway	ISO	J:155856
Biological Process	GO:0051966	regulation of synaptic transmission, glutamatergic	IMP	J:89486
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0051592	response to calcium ion	ISO	J:155856
Biological Process	GO:0061669	spontaneous neurotransmitter secretion	IMP	J:174823
Biological Process	GO:0048488	synaptic vesicle endocytosis	IBA	J:265628
Biological Process	GO:0016079	synaptic vesicle exocytosis	IMP	J:167753
Biological Process	GO:0071911	synchronous neurotransmitter secretion	IMP	J:174823
Biological Process	GO:0048278	vesicle docking	ISO	J:155856