GO Annotations Graph

• Symbol: Adcy2
• Name: adenylate cyclase 2
• ID: MGI:99676

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004016	adenylate cyclase activity	ISO	J:155856
Molecular Function	GO:0004016	adenylate cyclase activity	IBA	J:265628
Molecular Function	GO:0004016	adenylate cyclase activity	TAS	J:22804
Molecular Function	GO:0008179	adenylate cyclase binding	ISO	J:155856
Molecular Function	GO:0008179	adenylate cyclase binding	IPI	J:183218
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0031683	G-protein beta/gamma-subunit complex binding	ISO	J:155856
Molecular Function	GO:0016829	lyase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:155856
Molecular Function	GO:0030145	manganese ion binding	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0016849	phosphorus-oxygen lyase activity	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030425	dendrite	IDA	J:51838
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:51838
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:183218
Cellular Component	GO:0005886	plasma membrane	TAS	J:22804
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0007190	activation of adenylate cyclase activity	TAS	J:22804
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	TAS	J:51838
Biological Process	GO:0006171	cAMP biosynthetic process	ISO	J:155856
Biological Process	GO:0006171	cAMP biosynthetic process	IBA	J:265628
Biological Process	GO:0019933	cAMP-mediated signaling	ISO	J:155856
Biological Process	GO:1904322	cellular response to forskolin	ISO	J:155856
Biological Process	GO:0009190	cyclic nucleotide biosynthetic process	IEA	J:72247
Biological Process	GO:0035556	intracellular signal transduction	IEA	J:72247