GO Annotations Graph

• Symbol: Actn3
• Name: actinin alpha 3
• ID: MGI:99678

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:60000
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0051015	actin filament binding	TAS	J:32589
Molecular Function	GO:0051015	actin filament binding	IDA	J:93130
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:66484
Molecular Function	GO:0005515	protein binding	IPI	J:187422
Molecular Function	GO:0030674	protein-macromolecule adaptor activity	TAS	J:32589
Molecular Function	GO:0044325	transmembrane transporter binding	ISO	J:164563
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0030054	cell junction	IBA	J:265628
Cellular Component	GO:0042995	cell projection	IBA	J:265628
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0030017	sarcomere	IDA	J:121666
Cellular Component	GO:0030017	sarcomere	IDA	J:211364
Cellular Component	GO:0005865	striated muscle thin filament	TAS	J:32589
Cellular Component	GO:0030018	Z disc	IBA	J:265628
Cellular Component	GO:0030018	Z disc	IDA	J:158797
Cellular Component	GO:0030018	Z disc	IDA	J:158675
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0060349	bone morphogenesis	IMP	J:176471
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:164563
Biological Process	GO:0055001	muscle cell development	IBA	J:265628
Biological Process	GO:0006936	muscle contraction	TAS	J:32589
Biological Process	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	IMP	J:207120
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:222810
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:125639
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	IMP	J:133465
Biological Process	GO:0090324	negative regulation of oxidative phosphorylation	IMP	J:207120
Biological Process	GO:1901078	negative regulation of relaxation of muscle	IMP	J:133465
Biological Process	GO:1900159	positive regulation of bone mineralization involved in bone maturation	IMP	J:176471
Biological Process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	IMP	J:133465
Biological Process	GO:1904025	positive regulation of glucose catabolic process to lactate via pyruvate	IMP	J:125639
Biological Process	GO:0048743	positive regulation of skeletal muscle fiber development	IMP	J:133465
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	IMP	J:207120
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	IMP	J:133465
Biological Process	GO:1903715	regulation of aerobic respiration	IMP	J:125639
Biological Process	GO:0090257	regulation of muscle system process	IMP	J:133465
Biological Process	GO:0014728	regulation of the force of skeletal muscle contraction	IMP	J:125639
Biological Process	GO:0014894	response to denervation involved in regulation of muscle adaptation	IMP	J:207120
Biological Process	GO:0014732	skeletal muscle atrophy	IMP	J:207120
Biological Process	GO:0014883	transition between fast and slow fiber	IMP	J:125639