GO Annotations Graph

• Symbol: Tmbim6
• Name: transmembrane BAX inhibitor motif containing 6
• ID: MGI:99682

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0060698	endoribonuclease inhibitor activity	ISO	J:164563
Molecular Function	GO:0060698	endoribonuclease inhibitor activity	IMP	J:147348
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	IPI	J:147348
Molecular Function	GO:0019899	enzyme binding	IBA	J:265628
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0031966	mitochondrial membrane	ISO	J:164563
Cellular Component	GO:0031966	mitochondrial membrane	IBA	J:265628
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006914	autophagy	IEA	J:60000
Biological Process	GO:0034620	cellular response to unfolded protein	IMP	J:147348
Biological Process	GO:0034620	cellular response to unfolded protein	ISO	J:164563
Biological Process	GO:0034620	cellular response to unfolded protein	IBA	J:265628
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IDA	J:203180
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IDA	J:91831
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:91831
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:91831
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA	J:91831
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2001234	negative regulation of apoptotic signaling pathway	IBA	J:265628
Biological Process	GO:0010523	negative regulation of calcium ion transport into cytosol	ISO	J:230059
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI	J:203180
Biological Process	GO:0060702	negative regulation of endoribonuclease activity	ISO	J:164563
Biological Process	GO:0060702	negative regulation of endoribonuclease activity	IMP	J:147348
Biological Process	GO:0060702	negative regulation of endoribonuclease activity	IBA	J:265628
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0002638	negative regulation of immunoglobulin production	IMP	J:147348
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:0033119	negative regulation of RNA splicing	IMP	J:147348
Biological Process	GO:0033119	negative regulation of RNA splicing	ISO	J:164563
Biological Process	GO:0033119	negative regulation of RNA splicing	IBA	J:265628
Biological Process	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IMP	J:147348
Biological Process	GO:0036483	neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:91831
Biological Process	GO:0034976	response to endoplasmic reticulum stress	IMP	J:219082
Biological Process	GO:1902065	response to L-glutamate	ISO	J:164563
Biological Process	GO:0006986	response to unfolded protein	IEA	J:60000