GO Annotations Graph

• Symbol: Cttn
• Name: cortactin
• ID: MGI:99695

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0071933	Arp2/3 complex binding	ISO	J:155856
Molecular Function	GO:0005522	profilin binding	ISO	J:164563
Molecular Function	GO:0070064	proline-rich region binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:177198
Molecular Function	GO:0005515	protein binding	IPI	J:190005
Molecular Function	GO:0005515	protein binding	IPI	J:189997
Molecular Function	GO:0005515	protein binding	IPI	J:285007
Molecular Function	GO:0005515	protein binding	IPI	J:285007
Molecular Function	GO:0005515	protein binding	IPI	J:200313
Molecular Function	GO:0005515	protein binding	IPI	J:205642
Molecular Function	GO:0005515	protein binding	IPI	J:248259
Molecular Function	GO:0005515	protein binding	IPI	J:91030
Molecular Function	GO:0005515	protein binding	IPI	J:91030
Molecular Function	GO:0005515	protein binding	IPI	J:187579
Molecular Function	GO:0005515	protein binding	IPI	J:187581
Molecular Function	GO:0005515	protein binding	IPI	J:187581
Molecular Function	GO:0005515	protein binding	IPI	J:320065
Molecular Function	GO:0005515	protein binding	IPI	J:280803
Molecular Function	GO:0005515	protein binding	IPI	J:156238
Molecular Function	GO:0005515	protein binding	IPI	J:248263
Molecular Function	GO:0005515	protein binding	IPI	J:200426
Molecular Function	GO:0005515	protein binding	IPI	J:236216
Molecular Function	GO:0005515	protein binding	IPI	J:215888
Molecular Function	GO:0005515	protein binding	IPI	J:236216
Molecular Function	GO:0005515	protein binding	IPI	J:200486
Molecular Function	GO:0005515	protein binding	IPI	J:67836
Molecular Function	GO:0005515	protein binding	IPI	J:67836
Molecular Function	GO:0005515	protein binding	IPI	J:85107
Molecular Function	GO:0005515	protein binding	IPI	J:149136
Cellular Component	GO:0005884	actin filament	ISO	J:164563
Cellular Component	GO:0005884	actin filament	ISO	J:155856
Cellular Component	GO:0005884	actin filament	IBA	J:265628
Cellular Component	GO:0005938	cell cortex	ISO	J:164563
Cellular Component	GO:0005938	cell cortex	IDA	J:85107
Cellular Component	GO:0030054	cell junction	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005905	clathrin-coated pit	ISO	J:155856
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0030863	cortical cytoskeleton	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:85107
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-442844
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0030027	lamellipodium	IBA	J:265628
Cellular Component	GO:0030027	lamellipodium	IDA	J:85107
Cellular Component	GO:0030027	lamellipodium	IDA	J:84642
Cellular Component	GO:0030027	lamellipodium	IDA	J:149136
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:1990023	mitotic spindle midzone	IDA	J:205642
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0002102	podosome	IDA	J:129034
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	ISO	J:155856
Cellular Component	GO:0001726	ruffle	IDA	J:60368
Cellular Component	GO:0001726	ruffle	IDA	J:85107
Cellular Component	GO:0030427	site of polarized growth	IBA	J:265628
Cellular Component	GO:0045202	synapse	IEA	J:60000
Cellular Component	GO:0008076	voltage-gated potassium channel complex	IDA	J:215888
Cellular Component	GO:0008076	voltage-gated potassium channel complex	ISO	J:164563
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:155856
Biological Process	GO:0030041	actin filament polymerization	IEA	J:72247
Biological Process	GO:0048870	cell motility	ISO	J:155856
Biological Process	GO:0097062	dendritic spine maintenance	IGI	J:193891
Biological Process	GO:0006897	endocytosis	IEA	J:60000
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IGI	J:187651
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:155856
Biological Process	GO:0006886	intracellular protein transport	ISO	J:164563
Biological Process	GO:0006886	intracellular protein transport	IMP	J:215888
Biological Process	GO:0097581	lamellipodium organization	ISO	J:155856
Biological Process	GO:0098885	modification of postsynaptic actin cytoskeleton	ISO	J:155856
Biological Process	GO:0099010	modification of postsynaptic structure	ISO	J:155856
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IGI	J:187651
Biological Process	GO:0048812	neuron projection morphogenesis	ISO	J:155856
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:155856
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:164563
Biological Process	GO:0006898	receptor-mediated endocytosis	ISO	J:155856
Biological Process	GO:0030833	regulation of actin filament polymerization	IBA	J:265628
Biological Process	GO:1903146	regulation of autophagy of mitochondrion	IMP	J:217987
Biological Process	GO:0030516	regulation of axon extension	ISO	J:155856
Biological Process	GO:0060491	regulation of cell projection assembly	ISO	J:155856
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	IGI	J:149136