Runx2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Runx2
runt related transcription factor 2
MGI:99829

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:144188
Molecular Function	GO:0043425	bHLH transcription factor binding	IPI	J:144188
Molecular Function	GO:0003682	chromatin binding	IDA	J:138140
Molecular Function	GO:0003682	chromatin binding	IDA	J:94631
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:178159
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IMP	J:298907
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:40781
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:298907
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:163789
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:85208
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:90056
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:82780
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:155856
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:82780
Molecular Function	GO:0140296	general transcription initiation factor binding	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:94631
Molecular Function	GO:0005515	protein binding	IPI	J:118207
Molecular Function	GO:0005515	protein binding	IPI	J:182495
Molecular Function	GO:0005515	protein binding	IPI	J:165982
Molecular Function	GO:0005515	protein binding	IPI	J:186018
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:138140
Molecular Function	GO:0005515	protein binding	IPI	J:93345
Molecular Function	GO:0005515	protein binding	IPI	J:99840
Molecular Function	GO:0005515	protein binding	IPI	J:115876
Molecular Function	GO:0005515	protein binding	IPI	J:170631
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:90056
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:90056
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:40781
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	J:115876
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:171138
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:85208
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:89327
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:142858
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:82780
Cellular Component	GO:0000785	chromatin	IDA	J:125598
Cellular Component	GO:0005737	cytoplasm	IDA	J:117765
Cellular Component	GO:0005737	cytoplasm	IDA	J:117765
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8985328
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008004
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008009
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008063
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008077
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9008115
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009102
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009434
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009438
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009440
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2064924
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8865408
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8939880
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8940989
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985009
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985018
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985233
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985270
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8985623
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8986307
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007813
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007869
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008009
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008136
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008180
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008236
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008336
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008370
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008677
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008715
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008717
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9016554
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-8939977
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-8985474
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-8985490
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9008555
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9008636
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9009236
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:211112
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:144188
Cellular Component	GO:0005634	nucleus	IDA	J:95960
Cellular Component	GO:0005634	nucleus	IDA	J:117765
Cellular Component	GO:0005634	nucleus	IDA	J:117765
Cellular Component	GO:0005634	nucleus	IDA	J:80669
Cellular Component	GO:0005634	nucleus	IDA	J:290994
Cellular Component	GO:0005634	nucleus	IDA	J:82780
Cellular Component	GO:0005634	nucleus	IDA	J:93345
Cellular Component	GO:0032991	protein-containing complex	ISO	J:11868
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:115876
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:196266
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048469	cell maturation	IGI	J:89327
Biological Process	GO:0048469	cell maturation	IMP	J:95959
Biological Process	GO:0008283	cell population proliferation	IGI	J:191572
Biological Process	GO:0008283	cell population proliferation	IGI	J:107230
Biological Process	GO:0008283	cell population proliferation	IMP	J:112545
Biological Process	GO:0008283	cell population proliferation	IMP	J:112545
Biological Process	GO:0008283	cell population proliferation	IGI	J:107230
Biological Process	GO:0008283	cell population proliferation	IMP	J:112545
Biological Process	GO:0008283	cell population proliferation	IMP	J:112545
Biological Process	GO:0071773	cellular response to BMP stimulus	IMP	J:196266
Biological Process	GO:0002063	chondrocyte development	IMP	J:54095
Biological Process	GO:0002063	chondrocyte development	IMP	J:54095
Biological Process	GO:0002063	chondrocyte development	IMP	J:54095
Biological Process	GO:0002063	chondrocyte development	IMP	J:54095
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:107230
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0002062	chondrocyte differentiation	IGI	J:191689
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:191689
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:90056
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:90056
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:191689
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0001958	endochondral ossification	IMP	J:53540
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:112545
Biological Process	GO:0010467	gene expression	IDA	J:285968
Biological Process	GO:0030097	hemopoiesis	IBA	J:265628
Biological Process	GO:0036076	ligamentous ossification	IGI	J:191572
Biological Process	GO:0036076	ligamentous ossification	IGI	J:191572
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:142858
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:112545
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:112545
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IMP	J:92174
Biological Process	GO:0002076	osteoblast development	IGI	J:146013
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:164563
Biological Process	GO:0001649	osteoblast differentiation	ISO	J:155856
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:100164
Biological Process	GO:0001649	osteoblast differentiation	IGI	J:95960
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:95959
Biological Process	GO:0002051	osteoblast fate commitment	IGI	J:93345
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:107230
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0032332	positive regulation of chondrocyte differentiation	IMP	J:53540
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:298907
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:82780
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IMP	J:112545
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:171138
Biological Process	GO:0045778	positive regulation of ossification	ISO	J:155856
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:93345
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IDA	J:91833
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	IGI	J:146013
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:112545
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:40781
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:90056
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:144188
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:93345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:290994
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:138140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:115876
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:89327
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:138140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:94631
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:100164
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:93345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:80669
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:99840
Biological Process	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	IMP	J:196266
Biological Process	GO:0045595	regulation of cell differentiation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	IMP	J:92174
Biological Process	GO:0010468	regulation of gene expression	IDA	J:212995
Biological Process	GO:0042487	regulation of odontogenesis of dentin-containing tooth	IMP	J:87161
Biological Process	GO:0030278	regulation of ossification	IMP	J:54095
Biological Process	GO:0045667	regulation of osteoblast differentiation	IDA	J:173313
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0033591	response to L-ascorbic acid	IMP	J:178159
Biological Process	GO:0033591	response to L-ascorbic acid	IDA	J:178159
Biological Process	GO:1904383	response to sodium phosphate	IDA	J:201223
Biological Process	GO:0001501	skeletal system development	IMP	J:109399
Biological Process	GO:0001501	skeletal system development	IMP	J:87161
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:90056
Biological Process	GO:0060395	SMAD protein signal transduction	ISO	J:164563
Biological Process	GO:0007224	smoothened signaling pathway	IMP	J:112545
Biological Process	GO:0048863	stem cell differentiation	IDA	J:125119
Biological Process	GO:0072089	stem cell proliferation	IMP	J:112545
Biological Process	GO:0030217	T cell differentiation	IDA	J:22982

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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