Runx1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Runx1
runt related transcription factor 1
MGI:99852

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:115171
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:85208
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:85208
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:272739
Molecular Function	GO:0140297	DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0140297	DNA-binding transcription factor binding	IPI	J:82780
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:115171
Molecular Function	GO:0005515	protein binding	IPI	J:121433
Molecular Function	GO:0005515	protein binding	IPI	J:121433
Molecular Function	GO:0005515	protein binding	IPI	J:167439
Molecular Function	GO:0005515	protein binding	IPI	J:176461
Molecular Function	GO:0005515	protein binding	IPI	J:144706
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:121433
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:164563
Cellular Component	GO:0005604	basement membrane	IDA	J:116050
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0016513	core-binding factor complex	TAS	J:131081
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8937703
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8937738
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8955743
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-8955833
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9616215
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:121433
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:211575
Cellular Component	GO:0005634	nucleus	IDA	J:171374
Cellular Component	GO:0032991	protein-containing complex	ISO	J:11868
Biological Process	GO:0048266	behavioral response to pain	IMP	J:106971
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	IDA	J:204287
Biological Process	GO:0007417	central nervous system development	IMP	J:125796
Biological Process	GO:0060216	definitive hemopoiesis	IMP	J:54633
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:125796
Biological Process	GO:0031069	hair follicle morphogenesis	IMP	J:116050
Biological Process	GO:0030097	hemopoiesis	TAS	J:113799
Biological Process	GO:0030097	hemopoiesis	ISO	J:164563
Biological Process	GO:0030097	hemopoiesis	IBA	J:265628
Biological Process	GO:0001701	in utero embryonic development	IMP	J:125796
Biological Process	GO:0001889	liver development	IMP	J:125796
Biological Process	GO:0030099	myeloid cell differentiation	ISO	J:164563
Biological Process	GO:0002573	myeloid leukocyte differentiation	ISO	J:164563
Biological Process	GO:0002318	myeloid progenitor cell differentiation	IMP	J:146859
Biological Process	GO:0043371	negative regulation of CD4-positive, alpha-beta T cell differentiation	IDA	J:131081
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:211575
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:121433
Biological Process	GO:0030853	negative regulation of granulocyte differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:131081
Biological Process	GO:0048666	neuron development	IMP	J:106971
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0030182	neuron differentiation	IMP	J:91470
Biological Process	GO:0030182	neuron differentiation	IMP	J:91470
Biological Process	GO:0048663	neuron fate commitment	IMP	J:221586
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:63424
Biological Process	GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation	IDA	J:131081
Biological Process	GO:1903431	positive regulation of cell maturation	IMP	J:211575
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:167439
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	ISO	J:164563
Biological Process	GO:0032743	positive regulation of interleukin-2 production	IMP	J:121433
Biological Process	GO:0032743	positive regulation of interleukin-2 production	ISO	J:164563
Biological Process	GO:2000872	positive regulation of progesterone secretion	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:144706
Biological Process	GO:0032729	positive regulation of type II interferon production	IDA	J:121433
Biological Process	GO:0045595	regulation of cell differentiation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:272739
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:85208
Biological Process	GO:0071336	regulation of hair follicle cell proliferation	IMP	J:171374
Biological Process	GO:0009966	regulation of signal transduction	IMP	J:171374
Biological Process	GO:0002667	regulation of T cell anergy	IMP	J:121433
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0032526	response to retinoic acid	IDA	J:137480
Biological Process	GO:0001501	skeletal system development	IMP	J:95959

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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