GO Annotations Graph

• Symbol: Tie1
• Name: tyrosine kinase with immunoglobulin-like and EGF-like domains 1
• ID: MGI:99906

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	IEA	J:60000
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISM	J:15180
Cellular Component	GO:0005886	plasma membrane	IDA	J:125521
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0003180	aortic valve morphogenesis	IMP	J:281274
Biological Process	GO:0001568	blood vessel development	IMP	J:200671
Biological Process	GO:0060854	branching involved in lymph vessel morphogenesis	IMP	J:158668
Biological Process	GO:0001701	in utero embryonic development	IGI	J:67322
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	IMP	J:158668
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:79305
Biological Process	GO:0030336	negative regulation of cell migration	IMP	J:79305
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045026	plasma membrane fusion	IMP	J:79305
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0001936	regulation of endothelial cell proliferation	IMP	J:158668
Biological Process	GO:1901201	regulation of extracellular matrix assembly	IMP	J:281274
Biological Process	GO:0032526	response to retinoic acid	IDA	J:137480
Biological Process	GO:0048771	tissue remodeling	IMP	J:158668
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0001570	vasculogenesis	ISO	J:155856