GO Annotations Graph

• Symbol: Mecp2
• Name: methyl CpG binding protein 2
• ID: MGI:99918

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003682	chromatin binding	IBA	J:265628
Molecular Function	GO:0003682	chromatin binding	IDA	J:96437
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:136439
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IMP	J:117154
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:136439
Molecular Function	GO:0010385	double-stranded methylated DNA binding	ISO	J:155856
Molecular Function	GO:0010385	double-stranded methylated DNA binding	IBA	J:265628
Molecular Function	GO:0010385	double-stranded methylated DNA binding	IDA	J:86311
Molecular Function	GO:0010385	double-stranded methylated DNA binding	IDA	J:98000
Molecular Function	GO:0010385	double-stranded methylated DNA binding	ISS	J:125897
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:155856
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0008327	methyl-CpG binding	ISO	J:155856
Molecular Function	GO:0008327	methyl-CpG binding	IBA	J:265628
Molecular Function	GO:0008327	methyl-CpG binding	IDA	J:94991
Molecular Function	GO:0008327	methyl-CpG binding	IDA	J:117154
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140693	molecular condensate scaffold activity	ISO	J:164563
Molecular Function	GO:0003729	mRNA binding	IDA	J:94991
Molecular Function	GO:0003676	nucleic acid binding	ISO	J:164563
Molecular Function	GO:1990841	promoter-specific chromatin binding	ISO	J:155856
Molecular Function	GO:1990841	promoter-specific chromatin binding	IDA	J:110323
Molecular Function	GO:0005515	protein binding	IPI	J:242147
Molecular Function	GO:0005515	protein binding	IPI	J:177242
Molecular Function	GO:0005515	protein binding	IPI	J:306579
Molecular Function	GO:0005515	protein binding	IPI	J:306580
Molecular Function	GO:0005515	protein binding	IPI	J:182500
Molecular Function	GO:0005515	protein binding	IPI	J:118818
Molecular Function	GO:0005515	protein binding	IPI	J:158584
Molecular Function	GO:0005515	protein binding	IPI	J:158584
Molecular Function	GO:0005515	protein binding	IPI	J:203745
Molecular Function	GO:0005515	protein binding	IPI	J:203745
Molecular Function	GO:0005515	protein binding	IPI	J:304578
Molecular Function	GO:0005515	protein binding	IPI	J:203745
Molecular Function	GO:0005515	protein binding	IPI	J:263039
Molecular Function	GO:0005515	protein binding	IPI	J:125897
Molecular Function	GO:0005515	protein binding	IPI	J:136439
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:155856
Molecular Function	GO:0035197	siRNA binding	IDA	J:94991
Molecular Function	GO:0003714	transcription corepressor activity	ISO	J:164563
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:237322
Molecular Function	GO:0008134	transcription factor binding	IPI	J:86311
Molecular Function	GO:0045322	unmethylated CpG binding	ISO	J:155856
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:130115
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IDA	J:104568
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0000792	heterochromatin	ISO	J:164563
Cellular Component	GO:0000792	heterochromatin	IBA	J:265628
Cellular Component	GO:0000792	heterochromatin	IDA	J:125897
Cellular Component	GO:0000792	heterochromatin	IDA	J:86777
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9005848
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9005872
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9006014
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9006133
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9006494
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9006501
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007015
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017445
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017958
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9017986
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021849
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021887
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021925
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021968
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021969
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021971
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021973
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9021974
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022187
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022302
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022604
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022722
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022767
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022867
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022928
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9022931
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023138
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023364
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023371
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023529
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9023599
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9615549
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9615812
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:86311
Cellular Component	GO:0005634	nucleus	IDA	J:104568
Cellular Component	GO:0005634	nucleus	IDA	J:130772
Cellular Component	GO:0005634	nucleus	IDA	J:112812
Cellular Component	GO:0005634	nucleus	IDA	J:130115
Cellular Component	GO:0005634	nucleus	IDA	J:74625
Cellular Component	GO:0005634	nucleus	IDA	J:136439
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:137513
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:67910
Biological Process	GO:0008306	associative learning	IMP	J:225991
Biological Process	GO:0001662	behavioral fear response	IMP	J:137513
Biological Process	GO:0001662	behavioral fear response	IMP	J:112812
Biological Process	GO:0006576	biogenic amine metabolic process	IMP	J:102566
Biological Process	GO:0007420	brain development	IMP	J:139191
Biological Process	GO:0032048	cardiolipin metabolic process	IMP	J:129328
Biological Process	GO:0050432	catecholamine secretion	IMP	J:113437
Biological Process	GO:0008283	cell population proliferation	IMP	J:104568
Biological Process	GO:0071317	cellular response to isoquinoline alkaloid	ISO	J:155856
Biological Process	GO:0035865	cellular response to potassium ion	ISO	J:155856
Biological Process	GO:0021549	cerebellum development	IMP	J:139191
Biological Process	GO:0007268	chemical synaptic transmission	IMP	J:104113
Biological Process	GO:0016358	dendrite development	IMP	J:134828
Biological Process	GO:0016358	dendrite development	IMP	J:94370
Biological Process	GO:0009790	embryo development	IMP	J:31573
Biological Process	GO:0040029	epigenetic regulation of gene expression	IMP	J:98000
Biological Process	GO:0040029	epigenetic regulation of gene expression	IMP	J:134828
Biological Process	GO:0060079	excitatory postsynaptic potential	IMP	J:126964
Biological Process	GO:0010467	gene expression	IDA	J:287849
Biological Process	GO:0010467	gene expression	IMP	J:287849
Biological Process	GO:0014009	glial cell proliferation	IMP	J:104568
Biological Process	GO:0008211	glucocorticoid metabolic process	IMP	J:117154
Biological Process	GO:0006541	glutamine metabolic process	IMP	J:129328
Biological Process	GO:0031507	heterochromatin formation	IMP	J:96437
Biological Process	GO:0016573	histone acetylation	IMP	J:98000
Biological Process	GO:0016571	histone methylation	IMP	J:98000
Biological Process	GO:0006020	inositol metabolic process	IMP	J:129328
Biological Process	GO:0007612	learning	IMP	J:135825
Biological Process	GO:0007612	learning	IMP	J:137513
Biological Process	GO:0007616	long-term memory	IMP	J:104113
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:104545
Biological Process	GO:0007613	memory	IMP	J:104113
Biological Process	GO:0007052	mitotic spindle organization	ISO	J:164563
Biological Process	GO:0033555	multicellular organismal response to stress	IMP	J:117154
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	ISO	J:155856
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:1903860	negative regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0061000	negative regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:136439
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:117154
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0090327	negative regulation of locomotion involved in locomotory behavior	ISO	J:155856
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:130772
Biological Process	GO:2000635	negative regulation of primary miRNA processing	ISO	J:155856
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:155856
Biological Process	GO:1903941	negative regulation of respiratory gaseous exchange	ISO	J:155856
Biological Process	GO:0051151	negative regulation of smooth muscle cell differentiation	IMP	J:237322
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:96437
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:96437
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:81304
Biological Process	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	IDA	J:237322
Biological Process	GO:0001976	nervous system process involved in regulation of systemic arterial blood pressure	IMP	J:129856
Biological Process	GO:0050905	neuromuscular process	IMP	J:112812
Biological Process	GO:0050905	neuromuscular process	IMP	J:137513
Biological Process	GO:0050884	neuromuscular process controlling posture	IMP	J:67910
Biological Process	GO:0030182	neuron differentiation	IMP	J:287849
Biological Process	GO:0030182	neuron differentiation	IDA	J:287849
Biological Process	GO:0030182	neuron differentiation	IMP	J:109708
Biological Process	GO:0042551	neuron maturation	IMP	J:135669
Biological Process	GO:0042551	neuron maturation	IMP	J:94370
Biological Process	GO:0042551	neuron maturation	IMP	J:134828
Biological Process	GO:0031175	neuron projection development	IMP	J:109708
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:287849
Biological Process	GO:0046470	phosphatidylcholine metabolic process	IMP	J:129328
Biological Process	GO:1901953	positive regulation of anterograde dense core granule transport	ISO	J:155856
Biological Process	GO:1905492	positive regulation of branching morphogenesis of a nerve	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0060999	positive regulation of dendritic spine development	ISO	J:155856
Biological Process	GO:1905643	positive regulation of DNA methylation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:136439
Biological Process	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0060252	positive regulation of glial cell proliferation	IMP	J:104568
Biological Process	GO:1900114	positive regulation of histone H3-K9 trimethylation	IDA	J:237322
Biological Process	GO:0090063	positive regulation of microtubule nucleation	ISO	J:164563
Biological Process	GO:1901956	positive regulation of retrograde dense core granule transport	ISO	J:155856
Biological Process	GO:0031915	positive regulation of synaptic plasticity	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113437
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:113437
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:110323
Biological Process	GO:0009791	post-embryonic development	IMP	J:137513
Biological Process	GO:0019230	proprioception	IMP	J:135825
Biological Process	GO:0019230	proprioception	IMP	J:137513
Biological Process	GO:0008104	protein localization	IMP	J:125897
Biological Process	GO:0099611	regulation of action potential firing threshold	ISO	J:155856
Biological Process	GO:0044030	regulation of DNA methylation	ISO	J:155856
Biological Process	GO:0010468	regulation of gene expression	IDA	J:133420
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	ISO	J:73065
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:96437
Biological Process	GO:0051570	regulation of histone H3-K9 methylation	IMP	J:96437
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IMP	J:104053
Biological Process	GO:0002087	regulation of respiratory gaseous exchange by nervous system process	IMP	J:135825
Biological Process	GO:0050807	regulation of synapse organization	ISO	J:155856
Biological Process	GO:0048167	regulation of synaptic plasticity	IMP	J:104113
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IMP	J:137513
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	IMP	J:67910
Biological Process	GO:0042220	response to cocaine	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	IMP	J:130772
Biological Process	GO:0051707	response to other organism	IMP	J:130772
Biological Process	GO:0019233	sensory perception of pain	IMP	J:135825
Biological Process	GO:0035176	social behavior	ISO	J:155856
Biological Process	GO:0035176	social behavior	IMP	J:135825
Biological Process	GO:0035176	social behavior	IMP	J:112812
Biological Process	GO:0001964	startle response	IMP	J:135825
Biological Process	GO:0007416	synapse assembly	IMP	J:135669
Biological Process	GO:0007416	synapse assembly	IMP	J:126964
Biological Process	GO:0099191	trans-synaptic signaling by BDNF	IMP	J:113437
Biological Process	GO:0021591	ventricular system development	IMP	J:139191
Biological Process	GO:0008542	visual learning	IMP	J:104113