Jak3 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Jak3
Janus kinase 3
MGI:99928

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005126	cytokine receptor binding	IBA	J:265628
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:62510
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:19201
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:62510
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295758
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-1295764
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983294
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983313
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-8983356
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007126
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9007137
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9009867
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0030183	B cell differentiation	IMP	J:112031
Biological Process	GO:0030154	cell differentiation	IBA	J:265628
Biological Process	GO:0071345	cellular response to cytokine stimulus	IMP	J:150450
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IDA	J:19201
Biological Process	GO:0007167	enzyme-linked receptor protein signaling pathway	IDA	J:19201
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0035723	interleukin-15-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038110	interleukin-2-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0038113	interleukin-9-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:19201
Biological Process	GO:0048535	lymph node development	TAS	J:60454
Biological Process	GO:0002731	negative regulation of dendritic cell cytokine production	IMP	J:123902
Biological Process	GO:0045221	negative regulation of FasL production	IMP	J:112031
Biological Process	GO:0032693	negative regulation of interleukin-10 production	IMP	J:123902
Biological Process	GO:0032695	negative regulation of interleukin-12 production	IMP	J:123902
Biological Process	GO:0050868	negative regulation of T cell activation	IMP	J:112031
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	IMP	J:123902
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:106675
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:62510
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	ISO	J:155856
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:2000670	positive regulation of dendritic cell apoptotic process	IMP	J:123902
Biological Process	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP	J:123902
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	ISO	J:155856
Biological Process	GO:0042102	positive regulation of T cell proliferation	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:98326
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	IBA	J:265628
Biological Process	GO:0042981	regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0070232	regulation of T cell apoptotic process	IMP	J:112031
Biological Process	GO:0070672	response to interleukin-15	TAS	J:172922
Biological Process	GO:0070669	response to interleukin-2	TAS	J:106675
Biological Process	GO:0070670	response to interleukin-4	TAS	J:172922
Biological Process	GO:0070670	response to interleukin-4	ISO	J:164563
Biological Process	GO:0071104	response to interleukin-9	TAS	J:172922
Biological Process	GO:0043029	T cell homeostasis	IMP	J:112031
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:98326

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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