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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cfl1
cofilin 1, non-muscle
MGI:101757
38 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cfl1c5/Cfl1c5
involves: C57BL/6J 		abnormal cardiac outflow tract development J:194042
exencephaly J:194042
open neural tube J:194042
pericardial edema J:194042
wavy neural tube J:194042
Cfl1Gt(OST252839)Lex/Cfl1Gt(OST252839)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		preweaning lethality, complete penetrance J:103485
Cfl1tm1.1Wit/Cfl1tm1.1Wit
involves: 129 * C57BL/6 * SJL 		abnormal axon extension J:125317
abnormal cerebral cortex morphology J:125317
abnormal neurite morphology J:125317
abnormal neuron differentiation J:125317
abnormal neuronal precursor proliferation J:125317
ataxia J:125317
enlarged brain ventricles J:125317
postnatal growth retardation J:125317
postnatal lethality, incomplete penetrance J:125317
premature death J:125317
premature neuronal precursor differentiation J:125317
seizures J:125317
Cfl1tm1.1Wit/Cfl1tm1.1Wit
Tg(NPHS2-cre)295Lbh/0
involves: 129 * C57BL/6 * SJL 		abnormal podocyte foot process morphology J:165315
abnormal response to injury J:165315
ascites J:165315
disheveled coat J:165315
increased circulating creatinine level J:165315
increased urine protein level J:165315
podocyte microvillus transformation J:165315
premature death J:165315
normal renal/urinary system phenotype J:165315
Cfl1tm1.2Wit/Cfl1tm1.2Wit
involves: 129 		abnormal cardiac outflow tract development J:194042
abnormal eye development J:96452
abnormal neural crest cell delamination J:96452
abnormal neural crest cell migration J:96452
abnormal neural plate morphology J:96452
abnormal neural tube morphology J:96452
abnormal somite border morphology J:96452
abnormal somite development J:96452
absent head mesenchyme J:96452
decreased embryo size J:96452
decreased embryonic neuroepithelial cell proliferation J:96452
decreased embryonic neuroepithelium thickness J:96452
exencephaly J:194042
open neural tube J:96452, J:194042
prenatal lethality, complete penetrance J:96452
wavy neural tube J:194042
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory