About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cfl1
cofilin 1, non-muscle
MGI:101757
38 phenotypes from 4 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cfl1c5/Cfl1c5
involves: C57BL/6J 		abnormal cardiac outflow tract development J:194042
exencephaly J:194042
open neural tube J:194042
pericardial edema J:194042
wavy neural tube J:194042
Cfl1Gt(OST252839)Lex/Cfl1Gt(OST252839)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		preweaning lethality, complete penetrance J:103485
Cfl1tm1.1Wit/Cfl1tm1.1Wit
involves: 129 * C57BL/6 * SJL 		abnormal axon extension J:125317
abnormal cerebral cortex morphology J:125317
abnormal neurite morphology J:125317
abnormal neuron differentiation J:125317
abnormal neuronal precursor proliferation J:125317
ataxia J:125317
enlarged brain ventricles J:125317
postnatal growth retardation J:125317
postnatal lethality, incomplete penetrance J:125317
premature death J:125317
premature neuronal precursor differentiation J:125317
seizures J:125317
Cfl1tm1.1Wit/Cfl1tm1.1Wit
Tg(NPHS2-cre)295Lbh/0
involves: 129 * C57BL/6 * SJL 		abnormal podocyte foot process morphology J:165315
abnormal response to injury J:165315
ascites J:165315
disheveled coat J:165315
increased circulating creatinine level J:165315
increased urine protein level J:165315
podocyte microvillus transformation J:165315
premature death J:165315
normal renal/urinary system phenotype J:165315
Cfl1tm1.2Wit/Cfl1tm1.2Wit
involves: 129 		abnormal cardiac outflow tract development J:194042
abnormal eye development J:96452
abnormal neural crest cell delamination J:96452
abnormal neural crest cell migration J:96452
abnormal neural plate morphology J:96452
abnormal neural tube morphology J:96452
abnormal somite border morphology J:96452
abnormal somite development J:96452
absent head mesenchyme J:96452
decreased embryo size J:96452
decreased embryonic neuroepithelial cell proliferation J:96452
decreased embryonic neuroepithelium thickness J:96452
exencephaly J:194042
open neural tube J:96452, J:194042
prenatal lethality, complete penetrance J:96452
wavy neural tube J:194042
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory