Cdk5r1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cdk5r1
cyclin dependent kinase 5, regulatory subunit 1
MGI:101764

44 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cdk5r1^tm1Ivi/Cdk5r1^tm1Ivi B6.Cg-Cdk5r1^tm1Ivi	abnormal cerebellum morphology	J:86345
	abnormal stratification in cerebral cortex	J:86345
	delaminated Purkinje cell layer	J:86345
	ectopic cerebellar granule cells	J:86345
Cdk5r1^tm1Lht/Cdk5r1^tm1Lht involves: 129S4/SvJae	abnormal axon extension	J:193542
	abnormal behavioral response to xenobiotic	J:204269
	abnormal cerebellar molecular layer	J:38857
	abnormal cerebral cortex morphology	J:38857
	abnormal dentate gyrus morphology	J:38857
	abnormal forebrain development	J:38857
	abnormal forebrain morphology	J:38857
	abnormal hippocampus layer morphology	J:38857
	abnormal hippocampus morphology	J:38857
	abnormal innervation	J:204269
	abnormal olfactory bulb development	J:38857
	abnormal physiological response to xenobiotic	J:204269
	abnormal sensitization to xenobiotic	J:204269
	abnormal stratification in cerebral cortex	J:204269
	abnormal striatum morphology	J:38857
	decreased corpus callosum size	J:38857, J:204269
	dilated lateral ventricle	J:38857
	ectopic Purkinje cell	J:38857
	hyperactivity	J:204269
	increased cellular glucose import	J:204269
	increased serotonin level	J:204269
	premature death	J:38857
	reduced long-term potentiation	J:193542
	seizures	J:38857
Cdk5r1^tm1Lht/Cdk5r1^tm1Lht involves: 129S4/SvJae * C57BL/6	abnormal cerebellar molecular layer	J:38857
	abnormal cerebral cortex morphology	J:38857, J:71181
	abnormal cerebral cortex pyramidal cell morphology	J:38857
	abnormal dentate gyrus morphology	J:38857
	abnormal forebrain morphology	J:38857
	abnormal hippocampus layer morphology	J:38857
	abnormal hippocampus morphology	J:38857, J:71181
	abnormal olfactory bulb development	J:38857
	abnormal subplate morphology	J:71181
	decreased corpus callosum size	J:38857
	decreased striatum size	J:38857
	dilated lateral ventricle	J:38857
	ectopic Purkinje cell	J:38857
	increased susceptibility to pharmacologically induced seizures	J:38857
	premature death	J:38857
	seizures	J:38857
	thin cortical plate	J:38857
Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh involves: 129 * C57BL/6J	abnormal hippocampus granule cell morphology	J:100692
	abnormal hippocampus pyramidal cell morphology	J:100692
	abnormal spatial learning	J:100692
	impaired coordination	J:215344
	reduced long-term depression	J:100692
Cdk5r1^tm1Ohsh/Cdk5r1^tm1Ohsh Not Specified	increased thermal nociceptive threshold	J:105661
Cdk5r1^tm2.1Lht/Cdk5r1^tm2.1Lht B6.129-Cdk5r1^tm2.1Lht	abnormal excitatory postsynaptic potential	J:208030
	abnormal long-term depression	J:208030
	slow extinction of fear memory	J:208030
Cdk5r1^tm2Ohsh/Cdk5r1^tm2Ohsh Tg(Pcp2-cre)1Amc/0 involves: C57BL/6 * C57BL/6N	absent long-term depression	J:215344
	impaired coordination	J:215344
	impaired synaptic plasticity	J:215344
	normal nervous system phenotype	J:215344
	reduced long-term potentiation	J:215344

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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