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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdk5
cyclin dependent kinase 5
MGI:101765
42 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdk5tm1Bibb/Cdk5tm1Bibb
Tg(Prnp-cre/ERT)28.4Ics/0
involves: C57BL/6 * SJL 		abnormal contextual conditioning behavior J:124046
abnormal excitatory postsynaptic currents J:124046
abnormal excitatory postsynaptic potential J:124046
abnormal long-term potentiation J:124046
abnormal spatial learning J:124046
abnormal synaptic plasticity J:124046
increased post-tetanic potentiation J:124046
Cdk5tm1Kul/Cdk5tm1Kul
involves: 129S4/SvJae * C57BL/6 		abnormal cerebellar cortex morphology J:64289
abnormal cerebellar foliation J:64289
abnormal cerebral cortex morphology J:71181
abnormal cortical plate morphology J:71181
abnormal dentate gyrus morphology J:71181
abnormal facial nerve morphology J:64289
abnormal hippocampus layer morphology J:64289, J:71181
abnormal hypoglossal nerve morphology J:64289
abnormal locomotor behavior J:64289
abnormal motor neuron morphology J:64289, J:71181
abnormal olfactory bulb development J:71181
abnormal spinal cord ventral horn morphology J:64289
abnormal stratification in cerebral cortex J:64289
absent suckling reflex J:64289
chromatolysis J:71181
cyanosis J:64289
hypopnea J:64289
perinatal lethality, complete penetrance J:64289
unresponsive to tactile stimuli J:64289
weakness J:64289
Cdk5tm2Kul/Cdk5tm2Kul
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		no abnormal phenotype detected J:89561
Cdk5tm2Kul/Cdk5tm2Kul
Tg(Nefh-cre)12Kul/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal brain development J:89561
abnormal cerebellum development J:89561
abnormal hippocampus development J:89561
abnormal olfactory bulb development J:89561
Tg(RNU6-1-RNAi:Cdk5)#Chad/0
C57BL/6J-Tg(RNU6-1-RNAi:Cdk5)#Chad 		abnormal hair follicle dermal papilla morphology J:255707
abnormal hair follicle melanin granule distribution J:255707
abnormal melanogenesis J:255707
abnormal melanosome transport J:255707
abnormal skin condition J:255707
alopecia J:255707
diluted coat color J:255707
enlarged spinous cells J:255707
skin lesions J:255707
thick epidermis J:255707
thick epidermis stratum spinosum J:255707
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory