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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd86
CD86 antigen
MGI:101773
35 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd86tm1Shr/Cd86tm1Shr
B6.129S4-Cd86tm1Shr 		decreased T cell proliferation J:57613
increased interferon-gamma secretion J:57613
Cd86tm1Shr/Cd86tm1Shr
involves: 129S4/SvJae 		abnormal humoral immune response J:39089
absent spleen germinal center J:39089
decreased IgG level J:39089
Cd86tm1Shr/Cd86tm1Shr
NOD.129S4-Cd86tm1Shr 		abnormal action potential J:71352
abnormal dorsal root ganglion morphology J:71352
abnormal dorsal spinal root morphology J:71352
abnormal myelin sheath morphology J:71352
abnormal nerve conduction J:71352, J:142046
abnormal nervous system morphology J:71352
abnormal T cell proliferation J:142046
abnormal ventral spinal root morphology J:71352
decreased grip strength J:142046
decreased nerve conduction velocity J:142046
decreased regulatory T cell number J:93421
decreased susceptibility to autoimmune diabetes J:71352
decreased T cell proliferation J:93421
demyelination J:71352
hindlimb paralysis J:71352
increased autoantibody level J:142046
increased interferon-gamma secretion J:142046
increased susceptibility to autoimmune diabetes J:93421
muscular atrophy J:71352
paresis J:142046
Tg(H2-K-Cd86)7All/0
B6.Cg-Tg(H2-K-Cd86)7All 		abnormal inflammatory response J:112266
decreased B cell number J:112266
decreased CD4-positive, alpha-beta T cell number J:112266
increased CD8-positive, alpha-beta T cell number J:112266
increased T cell number J:112266
lymph node hyperplasia J:112266
lymphoid hyperplasia J:112266
Tg(H2-K-Cd86)7All/0
involves: BALB/c * C57BL/6 * CBA 		increased splenocyte number J:112266
lymph node hyperplasia J:112266
spleen hyperplasia J:112266
Tg(H2-K-Cd86)7All/0
involves: C57BL/6J * CBA 		abnormal B cell differentiation J:112475
decreased B cell number J:112475
increased CD4-positive, alpha-beta T cell number J:112475
increased CD8-positive, alpha-beta T cell number J:112475
Tg(H2-K-Cd86)27All/0
involves: C57BL/6J * CBA 		abnormal B cell differentiation J:112475
decreased B cell number J:112475
Tg(H2-K-Cd86)31All/0
involves: C57BL/6J * CBA 		increased CD4-positive, alpha-beta T cell number J:112475
increased CD8-positive, alpha-beta T cell number J:112475
Tg(Igh-6-Cd86)1Akab/0
involves: FVB 		abnormal CD4-positive, alpha-beta T cell physiology J:44271
decreased B cell number J:44271
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory