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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cd80
CD80 antigen
MGI:101775
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd80tm1Shr/Cd80tm1Shr
Cd86tm1Shr/Cd86tm1Shr
B6.129S4-Cd80tm1Shr Cd86tm1Shr 		brain inflammation J:57613
decreased susceptibility to experimental autoimmune encephalomyelitis J:57613
decreased T cell proliferation J:57613
increased interferon-gamma secretion J:57613
increased tumor necrosis factor secretion J:57613
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
129.SJL-Cd86tm2Shr 		abnormal meninges morphology J:78992
decreased cell proliferation J:78992
decreased interleukin-2 secretion J:78992
decreased susceptibility to experimental autoimmune encephalomyelitis J:78992
increased susceptibility to experimental autoimmune encephalomyelitis J:78992
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
involves: 129S4/SvJae 		abnormal lymph node B cell domain morphology J:39089
abnormal spleen morphology J:39089
abnormal T cell physiology J:57090
abnormal T cell proliferation J:57090
decreased IgG1 level J:39089
decreased IgG2a level J:39089
decreased IgG level J:39089
decreased regulatory T cell number J:113109, J:205441
increased IgG3 level J:39089
increased IgM level J:39089
increased susceptibility to autoimmune diabetes J:113109
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
involves: 129S4/SvJae * BALB/c 		abnormal T cell number J:112266
decreased double-positive T cell number J:112266
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
involves: 129S4/SvJae * C57BL/6J * SJL 		abnormal spinal cord meninges morphology J:78992
decreased cell proliferation J:78992
decreased susceptibility to experimental autoimmune encephalomyelitis J:78992
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
involves: 129S4/SvJae * NOD 		abnormal CD4-positive, alpha-beta T cell physiology J:61905
abnormal cytokine secretion J:61905
increased susceptibility to autoimmune diabetes J:61905
insulitis J:61905
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Ctla4tm1Shr/Ctla4tm1Shr
involves: 129S4/SvJae * BALB/c 		abnormal cytokine secretion J:57090
abnormal T cell physiology J:57090
increased T cell proliferation J:57090
Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
involves: 129S4/SvJae * FVB/N * NOD 		decreased regulatory T cell number J:113109
decreased susceptibility to autoimmune diabetes J:113109
insulitis J:113109
Tg(Ins1-Cd80)378Psoh/0
Tg(Ins2-GP)#Psoh/0
involves: C57BL/6 * FVB/N 		hyperglycemia J:209714
Tg(Ins1-Cd80)378Psoh/0
Tg(Ins2-GP)#Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2 * FVB/N 		absent pancreatic beta cells J:209714
cachexia J:209714
hyperglycemia J:209714
insulitis J:209714
ketosis J:209714
periinsulitis J:209714
premature death J:209714
Tg(Ins1-Cd80)378Psoh/0
Tg(TcrLCMV)327Sdz/0
involves: C57BL/6 * DBA/2 * FVB/N 		normal homeostasis/metabolism phenotype J:209714
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory