Mybl2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mybl2
myeloblastosis oncogene-like 2
MGI:101785

38 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mybl2^{tm1.1(KOMP)Vlcg}/Mybl2^{tm1.1(KOMP)Vlcg} C57BL/6N-Mybl2^{tm1.1(KOMP)Vlcg}/MbpMmucd	preweaning lethality, complete penetrance	J:211773
Mybl2^{tm1.1(KOMP)Vlcg}/Mybl2^{tm1.1(KOMP)Vlcg} C57BL/6N-Mybl2^{tm1.1(KOMP)Vlcg}/Ucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
Mybl2^tm1.1Epr/Mybl2^tm1.1Epr Tg(Mx1-cre)1Cgn/0 involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N	abnormal cell cycle	J:206816
	abnormal common lymphocyte progenitor cell morphology	J:206816
	abnormal hematopoietic cell number	J:206816
	abnormal myelopoiesis	J:206816
	decreased B cell number	J:206816
	decreased bone marrow cell number	J:206816
	decreased common myeloid progenitor cell number	J:206816
	decreased erythroid progenitor cell number	J:206816
	decreased hematopoietic stem cell number	J:206816
	decreased hematopoietic stem cell proliferation	J:206816
	decreased leukocyte cell number	J:206816
	decreased lymphocyte cell number	J:206816
	decreased neutrophil cell number	J:206816
	decreased splenocyte number	J:206816
	decreased T cell number	J:206816
	thrombocytopenia	J:206816
Mybl2^tm1.1Jof/Mybl2⁺ Tg(Zp3-cre)3Mrt/0 involves: 129S2/SvPas * C57BL/6 * FVB/N	abnormal erythrocyte morphology	J:196804
	abnormal myelopoiesis	J:196804
	anemia	J:196804
	anisocytosis	J:196804
	decreased erythrocyte cell number	J:196804
	decreased leukocyte cell number	J:196804
	decreased neutrophil cell number	J:196804
	enlarged spleen	J:196804
	increased bone marrow cell number	J:196804
	increased granulocyte number	J:196804
	increased leukemia incidence	J:196804
	increased leukocyte cell number	J:196804
	increased megakaryocyte cell number	J:196804
	increased monocyte cell number	J:196804
	increased number of Howell-Jolly bodies	J:196804
	myeloid hyperplasia	J:196804
	poikilocytosis	J:196804
	thrombocytopenia	J:196804
	thrombocytosis	J:196804
Mybl2^tm1.1Jof/Mybl2^tm1.1Jof involves: 129S2/SvPas * C57BL/6 * SJL	no abnormal phenotype detected	J:103413
Mybl2^tm1.1Jof/Mybl2^tm1.1Jof Tg(Mx1-cre)1Cgn/0 involves: 129S2/SvPas * C57BL/6 * CBA * SJL	abnormal cell cycle	J:103413
Mybl2^tm1Jof/Mybl2^tm1Jof involves: 129S2/SvPas	embryonic lethality between somite formation and embryo turning, complete penetrance	J:103413
Mybl2^tm1Sis/Mybl2^tm1Sis involves: C57BL/6 * CBA	abnormal inner cell mass morphology	J:57999
Mybl2^tm1Sis/Mybl2^tm1Sis involves: C57BL/6 * CBA	embryonic lethality between implantation and somite formation, complete penetrance	J:57999

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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