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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mtf1
metal response element binding transcription factor 1
MGI:101786
25 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mtf1Thyls-BALB/c/Mtf1Thyls-BALB/c
involves: BALB/c * MSM 		increased incidence of tumors by ionizing radiation induction J:71358
increased T cell derived lymphoma incidence J:71358
Mtf1Thyls-BALB/c/Mtf1Thyls-MSM
involves: BALB/c * MSM 		increased incidence of tumors by ionizing radiation induction J:71358, J:85264
increased T cell derived lymphoma incidence J:71358, J:85264
Mtf1tm1b(KOMP)Wtsi/Mtf1+
C57BL/6N-Mtf1tm1b(KOMP)Wtsi/J 		abnormal retina morphology J:211773
decreased circulating glucose level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating potassium level J:211773
Mtf1tm1b(KOMP)Wtsi/Mtf1tm1b(KOMP)Wtsi
C57BL/6N-Mtf1tm1b(KOMP)Wtsi/J 		abnormal craniofacial morphology J:211773
abnormal embryo size J:211773
abnormal forebrain morphology J:211773
anophthalmia J:211773
embryonic growth retardation J:211773
microphthalmia J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
Mtf1tm1Wsc/Mtf1tm1Wsc
involves: 129 * C57BL/6 		hepatic necrosis J:48216
increased cellular sensitivity to alkylating agents J:48216
lethality throughout fetal growth and development, complete penetrance J:48216
Mtf1tm1Wsc/Mtf1tm1Wsc
Not Specified 		dilated liver sinusoidal space J:91119
hepatic necrosis J:91119
lethality throughout fetal growth and development, complete penetrance J:91119
Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(Mx1-cre)1Cgn/0
Tg(UBC-Mtf1)1Wsc/0
involves: 129/Sv * C57BL/6 * CBA 		abnormal xenobiotic pharmacokinetics J:91119
decreased leukocyte cell number J:91119
decreased lymphocyte cell number J:91119
increased physiological sensitivity to xenobiotic J:91119
increased susceptibility to xenobiotic induced morbidity/mortality J:91119
Mtf1tm1Wsc/Mtf1tm1Wsc
Tg(UBC-Mtf1)1Wsc/0
Not Specified 		no abnormal phenotype detected J:91119
Mtf1tm2Wsc/Mtf1tm2Wsc
Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		abnormal liver physiology J:102512
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory