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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lig1
ligase I, DNA, ATP-dependent
MGI:101789
35 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lig1m1Anu/Lig1m1Anu
involves: C3H/HeH * C57BL/6JAnu 		anemia J:199856
increased nucleated erythrocyte cell number J:199856
pale liver J:199856
Lig1tm1Dwm/Lig1tm1Dwm
involves: 129P2/OlaHsd 		abnormal definitive hematopoiesis J:75962
abnormal DNA replication J:75962
anemia J:75962
normal cellular phenotype J:75962
chromosomal instability J:75962
decreased fibroblast proliferation J:75962
decreased hematocrit J:75962
enlarged spleen J:75962
increased bone marrow cell number J:75962
macrocytosis J:75962
reticulocytosis J:75962
Lig1tm1Dwm/Lig1tm1Dwm
involves: 129P2/OlaHsd * BALB/c 		abnormal blood cell morphology/development J:76371
abnormal erythropoiesis J:76371
abnormal liver development J:76371
absent erythrocytes J:76371
anemia J:76371
anisocytosis J:76371
decreased embryo size J:76371
decreased erythroid progenitor cell number J:76371
embryonic growth retardation J:76371
lethality throughout fetal growth and development, complete penetrance J:76371
liver hypoplasia J:76371
pallor J:76371
poikilocytosis J:76371
small liver J:76371
Lig1tm2Dwm/Lig1tm2Dwm
involves: 129P2/OlaHsd 		abnormal erythropoiesis J:75962
anemia J:75962
lethality throughout fetal growth and development, complete penetrance J:75962
Lig1tm3Dwm/Lig1tm3Dwm
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone marrow cell physiology J:77902
abnormal spleen physiology J:77902
abnormal thymus physiology J:77902
chromosomal instability J:77902
decreased body weight J:77902
decreased fibroblast proliferation J:77902
enlarged spleen J:77902
normal hematopoietic system phenotype J:77902
increased adenocarcinoma incidence J:77902
increased lymphoma incidence J:77902
increased tumor incidence J:77902
postnatal growth retardation J:77902
reticulocytosis J:77902
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory