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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Isl1
ISL1 transcription factor, LIM/homeodomain
MGI:101791
130 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aldh1a2tm1Soc/Aldh1a2tm2Soc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ 		abnormal motor neuron innervation pattern J:112635
decreased motor neuron number J:112635
Bcortm1.1Vjba/Bcor+
Isl1tm1(cre)Sev/Isl1+
involves: 129S1/Sv 		persistent truncus arteriosus J:296645
preweaning lethality, incomplete penetrance J:296645
Bcortm1.1Vjba/Y
Isl1tm1(cre)Sev/Isl1+
involves: 129S1/Sv 		abnormal aortic arch morphology J:296645
lethality throughout fetal growth and development J:296645
perimembraneous ventricular septal defect J:296645
persistent truncus arteriosus J:296645
preweaning lethality, complete penetrance J:296645
syndactyly J:296645
Bmp4tm4Blh/Bmp4tm4Blh
Isl1tm1(cre)Sev/Isl1+
involves: 129 * 129S6/SvEvTac 		abnormal embryonic cloaca development J:192045
abnormal external female genitalia morphology J:192045
abnormal fibula morphology J:192045
abnormal hindlimb bud morphology J:192045
abnormal limb development J:192045
abnormal renal/urinary system morphology J:192045
absent urinary bladder J:192045
anal stenosis J:192045
external male genitalia hypoplasia J:192045
renal hypoplasia J:192045
sirenomelia J:192045
Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr
Isl1tm1(cre)Sev/Isl1+
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal cardiomyocyte apoptosis J:107396
abnormal fetal cardiomyocyte proliferation J:107396
abnormal hindlimb bud morphology J:107396
abnormal hindlimb morphology J:107396
decreased cell proliferation J:107396
embryonic lethality during organogenesis, complete penetrance J:107396
persistent truncus arteriosus J:107396
small hindlimb buds J:107396
Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Isl1tm1(cre)Tmj/Isl1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon extension J:201695
abnormal proprioceptive neuron morphology J:201695
abnormal sensory neuron innervation pattern J:201695
absent gastric milk in neonates J:201695
bradykinesia J:201695
neonatal lethality, incomplete penetrance J:201695
normal nervous system phenotype J:201695
Casz1tm1.1Flc/Casz1tm1.1Flc
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL 		abnormal heart right ventricle morphology J:221324
abnormal heart shape J:221324
decreased mitotic index J:221324
heart right ventricle hypoplasia J:221324
lethality throughout fetal growth and development, complete penetrance J:221324
Dll4tm1Frad/Dll4+
Isl1tm1(cre)Tmj/Isl1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiac outflow tract development J:308916
abnormal pulmonary valve morphology J:308916
double outlet right ventricle J:308916
overriding aortic valve J:308916
ventricular septal defect J:308916
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Sev/Isl1+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss 		normal cardiovascular system phenotype J:142392
Epha4tm1.1Bzh/Epha4tm1.1Bzh
Isl1tm1(cre)Sev/Isl1+
Tg(Hlxb9-GFP)1Tmj/0
involves: 129S/Sv * Black Swiss * C57BL/6J * CD-1 * FVB/N 		abnormal abducens nerve morphology J:243785
abnormal innervation J:243785
Etv1tm1Wds/Etv1tm1.1Wds
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ 		abnormal proprioceptive neuron morphology J:83461
Fgf8tm1Mrc/Fgf8tm2Moon
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv * Black Swiss * C57BL/6 		abnormal cardiac epithelial to mesenchymal transition J:143444
abnormal cardiac outflow tract development J:143444
abnormal conotruncal ridge morphology J:143444
persistent truncus arteriosus J:143444
Fgf8tm2Moon/Fgf8tm1Mrc
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv 		abnormal heart right ventricle morphology J:109475
abnormal truncus arteriosus septation J:109475
embryonic lethality during organogenesis, incomplete penetrance J:109475
increased apoptosis J:109475
persistent truncus arteriosus J:109475
small pharyngeal arch J:109475
Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ 		decreased motor neuron number J:135403
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm2Sev/Isl1tm2Sev
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal dorsal root ganglion morphology J:141110
abnormal sensory neuron innervation pattern J:141110
abnormal trigeminal ganglion morphology J:141110
decreased chemical nociceptive threshold J:141110
dorsal root ganglion hypoplasia J:141110
neonatal lethality, complete penetrance J:141110
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Tmj/Isl1+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal heart development J:169213
Hand2tm1Dsr/Hand2tm2.1Dsr
Isl1tm1(cre)Tmj/Isl1+
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:169213
embryonic lethality during organogenesis, complete penetrance J:169213
heart right ventricle hypoplasia J:169213
increased apoptosis J:169213
Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv 		abnormal cardiac outflow tract development J:189007
abnormal interatrial septum morphology J:189007
atrial septal defect J:189007
atrioventricular septal defect J:189007
double outlet right ventricle J:189007
persistent truncus arteriosus J:189007
Isl1tm1(cre)Sev/Isl1+
Pax9tm1Rbal/Pax9tm1.1Hpt
involves: 129 * C57BL/6J 		aberrant origin of the right subclavian artery J:311535
abnormal common carotid artery morphology J:311535
normal craniofacial phenotype J:311535
double outlet right ventricle J:311535
ectopic thymus J:311535
interrupted aortic arch J:311535
preaxial polydactyly J:311535
thymus hypoplasia J:311535
ventricular septal defect J:311535
Isl1tm1(cre)Sev/Isl1+
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1.1Hpt
involves: 129 * CD-1 		aberrant origin of the right subclavian artery J:311535
abnormal hyoid bone greater horn morphology J:311535
abnormal hyoid bone lesser horn morphology J:311535
abnormal hyoid bone morphology J:311535
abnormal inferior horn of thyroid cartilage morphology J:311535
abnormal superior horn of thyroid cartilage morphology J:311535
craniofacial phenotype J:311535
neonatal lethality, complete penetrance J:311535
preaxial polydactyly J:311535
Isl1tm1(cre)Sev/Isl1+
Juntm4Wag/Jun+
Not Specified 		interrupted aortic arch, type b J:199412
Isl1tm1(cre)Sev/Isl1+
Tg(CAG-lacZ,-BMPR1A*,-EGFP)1Mis/0
involves: 129S7/SvEvBrd 		atrioventricular septal defect J:189007
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal dorsal root ganglion morphology J:100886
abnormal sensory neuron innervation pattern J:100886
abnormal sensory neuron morphology J:100886
decreased muscle spindle number J:100886
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
involves: 129X1/SvJ * C57BL/6 		axon degeneration J:109131
premature death J:109131
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3.1Jbr/Phox2btm3.1Jbr
involves: 129S2/SvPas * 129X1/SvJ 		abnormal pterygopalatine ganglion morphology J:157532
absent petrosal ganglion J:157532
Isl1tm1(cre)Tmj/Isl1+
Zfp503tm1Lif/Zfp503tm1Lif
Tg(CAG-cat,-EGFP)1Rbns/0
involves: 129 * 129X1/SvJ * C57BL/6 * C57BL/6J 		abnormal dorsal striatum morphology J:286635
abnormal striatum morphology J:286635
abnormal ventral striatum morphology J:286635
Isl1tm1Gan/Isl1tm2Gan
Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk
Tg(Six3-cre)69Frty/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		optic nerve hypoplasia J:134978
retina ganglion cell degeneration J:134978
Isl1tm1Tmj/Isl1tm1Tmj
Pou4f1tm1Et/Pou4f1tm1Et
involves: 129 * C57BL/6 		abnormal brain development J:141110
embryonic growth arrest J:141110
embryonic lethality during organogenesis, complete penetrance J:141110
Isl1tm2Gan/Isl1tm2Gan
Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk
Tg(Six3-cre)69Frty/?
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 		optic nerve hypoplasia J:134978
retina ganglion cell degeneration J:134978
Juntm1Pa/Juntm4Wag
Isl1tm1(cre)Sev/Isl1+
involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6J 		normal cardiovascular system phenotype J:199412
normal embryo phenotype J:199412
Juntm4Wag/Juntm4Wag
Isl1tm1(cre)Sev/Isl1+
involves: 129P2/OlaHsd * 129S/Sv 		abnormal aortic valve morphology J:199412
abnormal cardiac outflow tract development J:199412
abnormal pharyngeal arch artery morphology J:199412
abnormal pulmonary valve cusp morphology J:199412
abnormal pulmonary valve morphology J:199412
double outlet right ventricle J:199412
interrupted aortic arch, type b J:199412
normal mortality/aging J:199412
retroesophageal right subclavian artery J:199412
semilunar valve hyperplasia J:199412
ventricular septal defect J:199412
Maftm1.1Cbm/Maftm2.1Cbm
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL 		abnormal axon morphology J:181639
abnormal coat/ hair morphology J:181639
abnormal Meissner's corpuscle morphology J:181639
abnormal nervous system electrophysiology J:181639
abnormal pacinian corpuscle morphology J:181639
axon degeneration J:181639
decreased body weight J:181639
decreased nerve conduction velocity J:181639
decreased pacinian corpuscle number J:181639
impaired coordination J:181639
small pacinian corpuscles J:181639
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Sev/Isl1+
involves: 129 * C57BL/6 		abnormal cardiac outflow tract development J:214093
absent heart right ventricle J:214093
embryonic lethality during organogenesis, complete penetrance J:214093
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ * C57BL/6 		abnormal cardiac outflow tract development J:214093
abnormal conotruncal ridge morphology J:214093
abnormal heart right ventricle morphology J:214093
abnormal myocardial trabeculae morphology J:214093
cyanosis J:214093
decreased heart right ventricle size J:214093
double outlet right ventricle J:214093
heart right ventricle hypoplasia J:214093
perinatal lethality J:214093
persistent truncus arteriosus J:214093
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal muscle spindle morphology J:80793
abnormal proprioceptive neuron morphology J:80793
decreased Schwann cell number J:80793
Phox2btm3.1Jbr/Phox2btm3.1Jbr
Isl1tm1(cre)Tmj/Isl1+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal neuron differentiation J:155885
abnormal neuron physiology J:155885
decreased body size J:155885
postnatal lethality, complete penetrance J:155885
Rspo3tm1Arte/Rspo3tm1Arte
Isl1tm1(cre)Sev/Isl1+
involves: 129 * C57BL/6 		abnormal cardiac outflow tract development J:214093
abnormal heart right ventricle morphology J:214093
blood vessel congestion J:214093
embryonic lethality during organogenesis, complete penetrance J:214093
pericardial edema J:214093
thin myocardium J:214093
Rspo3tm1Arte/Rspo3tm1Arte
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ * C57BL/6 		decreased heart right ventricle size J:214093
double outlet right ventricle J:214093
lethality throughout fetal growth and development, complete penetrance J:214093
pericardial edema J:214093
Smotm1Amc/Smotm2Amc
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv * 129X1/SvJ 		abnormal aortic arch morphology J:110602
abnormal cardiac neural crest cell migration J:110602
abnormal cardiac outflow tract development J:110602
abnormal sixth pharyngeal arch artery morphology J:110602
atrial septal defect J:110602
perinatal lethality J:110602
persistent truncus arteriosus J:110602
right aortic arch J:110602
transposition of great arteries J:110602
ventricular septal defect J:110602
Smotm2Amc/Smotm2Amc
Isl1tm1(cre)Tmj/Isl1+
involves: 129S/Sv * 129X1/SvJ 		abnormal blood circulation J:204743
abnormal heart right ventricle morphology J:204743
blood vessel atresia J:204743
persistent truncus arteriosus J:204743
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Isl1tm1(cre)Tmj/Isl1+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal cerebral cortex morphology J:201695
normal behavior/neurological phenotype J:201695
decreased tumor-free survival time J:201695
increased gastrointestinal tumor incidence J:201695
normal nervous system phenotype J:201695
thin cerebral cortex J:201695
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory