Msh2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Msh2
mutS homolog 2
MGI:101816

32 phenotypes from 7 alleles in 10 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Msh2^tm1Htr/Msh2⁺ involves: 129P2/OlaHsd	increased hemangiosarcoma incidence	J:45433
	increased liver tumor incidence	J:45433
	increased lung tumor incidence	J:45433
	increased mammary gland tumor incidence	J:45433
	increased osteosarcoma incidence	J:45433
	increased skin tumor incidence	J:45433
	increased tumor incidence	J:45433
	increased uterus tumor incidence	J:45433
	premature death	J:45433
Msh2^tm1Htr/Msh2^tm1Htr either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * FVB)	increased T cell derived lymphoma incidence	J:27469
Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd	abnormal class switch recombination	J:80893
	abnormal inflammatory response	J:80893
	abnormal somatic hypermutation frequency	J:155454
	decreased IgG1 level	J:80893
	decreased IgG3 level	J:80893
	normal immune system phenotype	J:47993
	increased brain tumor incidence	J:45433
	increased gastrointestinal tumor incidence	J:45433
	increased lymphoma incidence	J:45433
	increased skin tumor incidence	J:45433
	increased T cell derived lymphoma incidence	J:45433
	increased tumor incidence	J:45433
	premature death	J:45433
Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd * FVB	increased gastrointestinal tumor incidence	J:45433
	increased incidence of tumors by chemical induction	J:45433
	increased lung tumor incidence	J:45433
	increased lymphoma incidence	J:45433
	increased mammary gland tumor incidence	J:45433
	increased skin tumor incidence	J:45433
	increased T cell derived lymphoma incidence	J:45433
	increased tumor incidence	J:45433
	increased uterus tumor incidence	J:45433
	premature death	J:45433
Msh2^tm1Mak/Msh2^tm1Mak C57BL/6NTac-Msh2^tm1Mak	abnormal class switch recombination	J:326431
Msh2^tm1Mak/Msh2^tm1Mak C57BL/6NTac-Msh2^tm1Mak	abnormal somatic hypermutation frequency	J:326431
Msh2^tm1Mak/Msh2^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	normal immune system phenotype	J:28397
	increased lymphoma incidence	J:28397
	premature death	J:28397
Msh2^tm1Rak/Msh2⁺ involves: 129P2/OlaHsd	colon polyps	J:64667
	increased liver adenoma incidence	J:64667
	increased lymphoma incidence	J:64667
	increased tumor incidence	J:64667
Msh2^tm1Rak/Msh2^tm1Rak involves: 129P2/OlaHsd	abnormal class switch recombination	J:56764
	decreased mature B cell number	J:56764
	increased gastrointestinal tumor incidence	J:64667
	increased lymphoma incidence	J:64667
	premature death	J:64667
Msh2^tm1Rak/Msh2^tm1Rak involves: 129P2/OlaHsd * C57BL/6	increased lymphoma incidence	J:98929
Msh2^tm1Rak/Msh2^tm1Rak involves: 129P2/OlaHsd * C57BL/6	premature death	J:98929
Msh2^tm1Rak/Msh2^tm2.1Rak Tg(Vil1-cre)20Syr/0 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL	abnormal mismatch repair	J:161577
	abnormal physiological response to xenobiotic	J:161577
	abnormal tumor morphology	J:161577
	increased gastrointestinal tumor incidence	J:161577
	increased intestinal adenocarcinoma incidence	J:161577
	increased intestinal adenoma incidence	J:161577
Msh2^tm1Whl/Msh2^tm1Whl involves: 129P2/OlaHsd * C57BL/6J	abnormal tumor morphology	J:79016
	increased gastrointestinal tumor incidence	J:79016
	increased lymphoblastic lymphoma incidence	J:79016
	increased skin tumor incidence	J:79016
	increased squamous cell carcinoma incidence	J:79016
	premature death	J:79016
Msh2^tm2.1Rak/Msh2^tm2.1Rak involves: 129/Sv * C57BL/6 * C57BL/6J * SJL	normal neoplasm	J:161577
Msh2^tm2.1Rak/Msh2^tm2.1Rak Tg(Vil1-cre)20Syr/0 involves: 129/Sv * C57BL/6 * FVB/N * SJL	abnormal mismatch repair	J:161577
	increased gastrointestinal tumor incidence	J:161577
	increased intestinal adenoma incidence	J:161577
	increased lymphoma incidence	J:161577
	increased small intestine adenocarcinoma incidence	J:161577
	premature death	J:161577
Msh2^tm2.1Rak/Msh2^tm3.1Rak Tg(Vil1-cre)20Syr/0 involves: 129/Sv * C57BL/6 * DBA/2 * SJL	abnormal mismatch repair	J:161577
	abnormal physiological response to xenobiotic	J:161577
	abnormal tumor morphology	J:161577
	increased gastrointestinal tumor incidence	J:161577
	increased intestinal adenocarcinoma incidence	J:161577
	increased intestinal adenoma incidence	J:161577
Msh2^tm2.2Rak/Msh2^tm2.2Rak involves: 129/Sv * C57BL/6 * FVB/N * SJL	abnormal mismatch repair	J:161577
	increased gastrointestinal tumor incidence	J:161577
	increased lymphoma incidence	J:161577
	premature death	J:161577

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