Msh2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Msh2
mutS homolog 2
MGI:101816

40 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Msh2^tm1Mak/Msh2⁺ Nos2^tm1Mrl/Nos2^tm1Mrl involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	intestine polyps	J:200824
Apc^Min/Apc⁺ Msh2^tm1Mak/Msh2^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	anemia	J:75393
	increased intestinal adenoma incidence	J:75393
	intestinal obstruction	J:75393
	intestine polyps	J:200824
	premature death	J:75393
Apc^Min/Apc⁺ Msh2^tm1Mak/Msh2^tm1Mak Nos2^tm1Mrl/Nos2^tm1Mrl involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	intestine polyps	J:200824
Apc^Min/Apc⁺ Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd * BALB/c * C57BL/6J	increased gastrointestinal tumor incidence	J:45433
	premature death	J:45433
Apc^tm1Rak/Apc⁺ Msh2^tm1Rak/Msh2^tm1Rak involves: 129P2/OlaHsd	increased tumor incidence	J:64667
	premature death	J:64667
B4galnt2^a/B4galnt2^b Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd * BALB/c * SWR	decreased enterocyte apoptosis	J:54082
Fam72a^{tm1.1(KOMP)Vlcg}/Fam72a^{tm1.1(KOMP)Vlcg} Msh2^tm1Mak/Msh2^tm1Mak C57BL/6NTac-Fam72a^{tm1.1(KOMP)Vlcg} Msh2^tm1Mak	abnormal class switch recombination	J:326431
	abnormal somatic hypermutation frequency	J:326431
Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd	increased incidence of tumors by UV-induction	J:79734
	increased lymphoma incidence	J:79734
	increased mortality induced by ionizing radiation	J:79734
	increased skin papilloma incidence	J:79734
	increased skin squamous cell carcinoma incidence	J:79734
	increased skin tumor incidence	J:79734
	premature death	J:79734
Hr^hr/Hr^hr Msh2^tm1Htr/Msh2^tm1Htr Xpa^tm1Tnka/Xpa^tm1Tnka involves: 129P2/OlaHsd * C57BL/6 * CBA	increased incidence of tumors by UV-induction	J:79734
	increased lymphoma incidence	J:79734
	increased mortality induced by ionizing radiation	J:79734
	increased skin papilloma incidence	J:79734
	increased skin squamous cell carcinoma incidence	J:79734
	increased skin tumor incidence	J:79734
	premature death	J:79734
Htt^tm5Mem/Htt⁺ Msh2^tm1Htr/Msh2^tm1Htr involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 * FVB/N	neuronal intranuclear inclusions	J:81666
Msh2^tm1Htr/Msh2^tm1Htr Pcna^tm1Jcbs/Pcna^tm1Jcbs involves: 129P2/OlaHsd	abnormal somatic hypermutation frequency	J:155454
Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	increased lymphoma incidence	J:197809
	increased tumor incidence	J:197809
	premature death	J:197809
	preweaning lethality, incomplete penetrance	J:197809
Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	increased lymphoma incidence	J:197809
	increased tumor incidence	J:197809
	premature death	J:197809
	preweaning lethality, incomplete penetrance	J:197809
Msh2^tm1Htr/Msh2^tm1Htr Tap1^tm1Hpl/Tap1^tm1Hpl involves: 129P2/OlaHsd * FVB	increased gastrointestinal tumor incidence	J:45433
	increased lung tumor incidence	J:45433
	increased mammary gland tumor incidence	J:45433
	increased skin tumor incidence	J:45433
	increased tumor incidence	J:45433
	increased uterus tumor incidence	J:45433
Msh2^tm1Mak/Msh2⁺ Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld involves: 129 * C57BL/6J	increased lung adenocarcinoma incidence	J:89742
	increased lung adenoma incidence	J:89742
	increased lymphoma incidence	J:89742
	increased ovary tumor incidence	J:89742
	increased tumor incidence	J:89742
	premature death	J:89742
Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld involves: 129 * C57BL/6J	increased lung adenoma incidence	J:89742
	increased lymphoma incidence	J:89742
	increased tumor incidence	J:89742
	premature death	J:89742
Msh2^tm1Rak/Msh2^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	postnatal lethality, complete penetrance	J:153684
Msh2^tm1Rak/Msh2^tm1Rak Pole^tm1.1Bdp/Pole^tm1.1Bdp involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	postnatal lethality, complete penetrance	J:153684
Msh2^tm1Rak/Msh2^tm1Rak Xpc^tm1Ecf/Xpc^tm1Ecf involves: 129P2/OlaHsd * SKH1	abnormal cell cycle	J:94447
	increased cellular sensitivity to ultraviolet irradiation	J:94447
Msh2^tm1Tts/Msh2^tm1Tts Nudt1^tm1Tts/Nudt1^tm1Tts involves: 129S/SvEv * C57BL/6J	abnormal cell physiology	J:79732
Msh2^tm1Wed/Msh2^tm1Wed involves: 129 * C57BL/6 * SJL	abnormal mismatch repair	J:88092
	decreased survivor rate	J:88092
	increased intestinal adenocarcinoma incidence	J:88092
	increased lymphoma incidence	J:88092
	increased tumor incidence	J:88092
	increased tumor latency	J:88092
	premature death	J:88092
Msh2^tm1Wed/Msh2^tm1Wed involves: C57BL/6	abnormal class switch recombination	J:86278
	decreased IgG level	J:86278
	increased intestinal adenocarcinoma incidence	J:86278
	increased lymphoma incidence	J:86278
Msh2^tm1Whl/Msh2^tm1Whl Rb1^tm1Brd/Rb1⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	abnormal definitive hematopoiesis	J:79016
	abnormal tumor morphology	J:79016
	increased gastrointestinal tumor incidence	J:79016
	increased lymphoblastic lymphoma incidence	J:79016
	increased pheochromocytoma incidence	J:79016
	increased pituitary adenohypophysis tumor incidence	J:79016
	increased pituitary melanotroph tumor incidence	J:79016
	increased skin tumor incidence	J:79016
	increased thyroid C-cell carcinoma incidence	J:79016
	increased tumor incidence	J:79016
	premature death	J:79016
Msh2^tm1Whl/Msh2^tm1Whl Rb1^tm1Brd/Rb1^tm1Brd involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	abnormal definitive hematopoiesis	J:79016

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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