Traf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Traf2
TNF receptor-associated factor 2
MGI:101835

43 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Traf2^tm1Rbr/Traf2^tm1Rbr involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:132877
	increased follicular B cell number	J:132877
	increased marginal zone B cell number	J:132877
	lymph node hyperplasia	J:132877
Tg(Lck-cre)I57Jxm/? Traf2^tm1Rbr/Traf2^tm1Rbr involves: C57BL/6 * ICR	absent follicular B cells	J:132877
	absent marginal zone B cells	J:132877
	decreased mature B cell number	J:132877
Tg(Mx1-cre)1Cgn/0 Traf2^tm1Rbr/Traf2^tm1Rbr involves: C57BL/6 * CBA	abnormal spleen marginal zone morphology	J:93890
	abnormal spleen morphology	J:93890
	enlarged lymph nodes	J:93890
	enlarged spleen	J:93890
	increased B cell number	J:93890
	increased marginal zone B cell number	J:93890
Traf2^tm1.1Rbr/Traf2^tm1.1Rbr C57BL/6-Traf2^tm1.1Rbr	prenatal lethality, complete penetrance	J:93890
Traf2^{tm1a(EUCOMM)Wtsi}/Traf2⁺ C57BL/6N-Traf2^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased alpha-beta T cell number	J:211773
	decreased CD8-positive, alpha-beta T cell number	J:211773
	increased circulating chloride level	J:211773
Traf2^{tm1a(EUCOMM)Wtsi}/Traf2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Traf2^{tm1a(EUCOMM)Wtsi}/Wtsi	abnormal placenta morphology	J:261316
	abnormal placental labyrinth vasculature morphology	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	placenta hemorrhage	J:261316
	placenta necrosis	J:261316
	preweaning lethality, complete penetrance	J:211773
Traf2^tm1Mak/Traf2^tm1Mak either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6J)	abnormal cell physiology	J:44360
	absent lymph node germinal center	J:44360
	absent spleen germinal center	J:44360
	cachexia	J:44360
	decreased body fat mass	J:44360
	decreased body size	J:44360
	decreased double-positive T cell number	J:44360
	decreased immature B cell number	J:44360
	decreased lymphocyte cell number	J:44360
	decreased skeletal muscle mass	J:44360
	decreased thymocyte number	J:44360
	increased circulating tumor necrosis factor level	J:44360
	increased granulocyte number	J:44360
	increased sensitivity to induced cell death	J:44360
	increased thymocyte apoptosis	J:44360
	lymphoid hypoplasia	J:44360
	postnatal lethality, incomplete penetrance	J:44360
	spleen atrophy	J:44360
	thymus atrophy	J:44360
Traf2^tm1Mak/Traf2^tm1Mak involves: 129P2/OlaHsd * BALB/c * C57BL/6J	postnatal lethality, incomplete penetrance	J:44360
Traf2^tm1Mak/Traf2^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	lethality throughout fetal growth and development, incomplete penetrance	J:44360
	perinatal lethality, incomplete penetrance	J:44360
	postnatal lethality, incomplete penetrance	J:44360

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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