Tcf12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tcf12
transcription factor 12
MGI:101877

14 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tcf12^m1Btlr/Tcf12^m1Btlr C57BL/6J-Tcf12^M1Btlr	increased CD8-positive, alpha-beta T cell number	J:267564
Tcf12^M2Btlr/Tcf12^M2Btlr C57BL/6J-Tcf12^M2Btlr	decreased CD4-positive, alpha-beta T cell number	J:267666
	increased CD8-positive, alpha-beta T cell number	J:267666
	increased effector memory CD4-positive, alpha-beta T cell number	J:267666
Tcf12^M3Btlr/Tcf12^M3Btlr C57BL/6J-Tcf12^M3Btlr	decreased B cell number	J:271971
	decreased CD4-positive, alpha-beta T cell number	J:271971
	increased CD8-positive, alpha-beta T cell number	J:271971
Tcf12^m4Btlr/Tcf12^m4Btlr C57BL/6J-Tcf12^m4Btlr	abnormal B cell morphology	J:271972
	abnormal T cell morphology	J:271972
	decreased CD4-positive, alpha-beta T cell number	J:271972
	increased CD8-positive, alpha-beta T cell number	J:271972
Tcf12^tm1Zhu/Tcf12^tm1Zhu involves: 129/Sv * C57BL/6	decreased pro-B cell number	J:43324
Tcf12^tm1Zhu/Tcf12^tm1Zhu involves: 129/Sv * C57BL/6	postnatal lethality, complete penetrance	J:43324
Tcf12^tm1Zhu/Tcf12^tm1Zhu involves: 129S7/SvEvBrd	arrested T cell differentiation	J:120411
	decreased thymocyte number	J:120411
	normal nervous system phenotype	J:125313
Tcf12^tm1Zhu/Tcf12^tm1Zhu involves: 129S7/SvEvBrd * C57BL/6J	decreased double-positive T cell number	J:136143
	increased CD8-positive, alpha-beta T cell number	J:136143
	increased double-negative T cell number	J:136143
	thymus hypoplasia	J:136143
Tcf12^tm3Zhu/Tcf12^tm3Zhu Tg(Lck-cre)#Zhu/0 involves: C57BL/6 * SJL/J	decreased thymocyte number	J:129570
	increased CD8-positive, alpha-beta T cell number	J:129570

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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