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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppard
peroxisome proliferator activator receptor delta
MGI:101884
106 phenotypes from 12 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ppardtm1.1Rev/Ppardtm1.1Rev
Not Specified 		abnormal adipose tissue morphology J:73557
abnormal fat cell morphology J:73557
abnormal placenta development J:73557
decreased abdominal fat pad weight J:73557
decreased interscapular fat pad weight J:73557
decreased mesenteric fat pad weight J:73557
decreased placental labyrinth size J:73557
decreased subcutaneous adipose tissue amount J:73557
embryonic growth retardation J:73557
embryonic lethality during organogenesis, incomplete penetrance J:73557
Ppardtm1Dgen/Ppard+
involves: 129P2/OlaHsd * C57BL/6 		decreased thermal nociceptive threshold J:101679
Ppardtm1Dgen/Ppardtm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		dilated lateral ventricle J:101679
embryonic lethality during organogenesis, incomplete penetrance J:101679
Ppardtm1Dsvg/Ppardtm1Dsvg
involves: 129S2/SvPas 		abnormal placenta development J:107381
embryonic growth retardation J:107381
embryonic lethality during organogenesis, incomplete penetrance J:107381
postnatal growth retardation J:107381
reduced fertility J:107381
Ppardtm1Dsvg/Ppardtm1Dsvg
involves: 129S2/SvPas * C57BL/6 		abnormal bone ossification J:219677
abnormal circulating protein level J:219677
abnormal compact bone morphology J:219677
abnormal compact bone volume J:219677
abnormal response to exercise J:219677
decreased aerobic running capacity J:219677
decreased bone mineral density J:219677
decreased bone mineral density of femur J:219677
decreased bone stiffness J:219677
decreased bone strength J:219677
decreased bone volume J:219677
decreased energy dissipated prior to femur fracture J:219677
decreased lean body mass J:219677
decreased skeletal muscle mass J:219677
impaired glucose tolerance J:219677
impaired osteoblast differentiation J:219677
increased bone marrow adipose tissue amount J:219677
increased bone resorption J:219677
increased osteoclast cell number J:219677
muscle weakness J:219677
Ppardtm1Jps/Ppardtm1Jps
involves: 129/Sv * C57BL/6N 		abnormal brain morphology J:63040
abnormal energy expenditure J:63040
abnormal gonadal fat pad morphology J:63040
abnormal lipid level J:76564
abnormal myelination J:63040
decreased body size J:63040
decreased brain size J:63040
decreased fetal size J:63040
decreased liver cholesterol level J:89827
decreased liver triglyceride level J:89827
epidermal hyperplasia J:63040
increased circulating triglyceride level J:89827
increased circulating VLDL cholesterol level J:89827
increased fatty acids level J:89827
increased incidence of tumors by chemical induction J:90217, J:90337
increased intestinal adenocarcinoma incidence J:90217
increased sebaceous gland adenoma incidence J:90337
increased skin papilloma incidence J:90337
increased skin tumor incidence J:90337
increased total body fat amount J:89827
increased tumor incidence J:90337
intestine polyps J:90217
prenatal lethality J:63040
skin inflammation J:63040
Ppardtm1Mtz/Ppardtm1Mtz
Tg(KRT14-cre)1Ipc/0
involves: C57BL/6 * SJL 		abnormal epidermal layer morphology J:109090
abnormal keratinocyte morphology J:109090
abnormal skin condition J:109090
abnormal skin morphology J:109090
decreased cholesterol level J:109090
Ppardtm1Rev/Ppardtm1Rev
Tg(Fabp4-cre)1Rev/0
Not Specified 		normal adipose tissue phenotype J:73557
Ppardtm1Wwah/Ppard+
Not Specified 		abnormal keratinocyte adhesion J:71272
delayed wound healing J:71272
increased keratinocyte proliferation J:71272
thick epidermis J:71272
Ppardtm1Wwah/Ppardtm1Wwah
Not Specified 		abnormal hair follicle development J:96826
abnormal hair follicle peg morphology J:96826
decreased keratinocyte proliferation J:96826
increased keratinocyte apoptosis J:96826
prenatal lethality, incomplete penetrance J:71272
thin hypodermis J:96826
thin skin J:96826
underdeveloped hair follicles J:96826
Ppardtm1Yjj/Ppardtm1Yjj
involves: 129 		abnormal epidermis stratum corneum morphology J:182124
abnormal stratum corneum lipid matrix formation J:182124
Ppardtm2Rev/Ppardtm2Rev
involves: 129S4/SvJae 		abnormal extraembryonic tissue morphology J:105694
prenatal lethality, complete penetrance J:105694
Rgs9tm1.1(cre)Yql/Rgs9+
Tg(CAG-Ppard*E411P)#Als/0
B6J.Cg-Rgs9tm1.1(cre)Yql Tg(CAG-Ppard*E411P)#Als 		abnormal medium spiny neuron morphology J:233176
abnormal motor capabilities/coordination/movement J:233176
decreased grip strength J:233176
impaired coordination J:233176
kyphosis J:233176
limb grasping J:233176
neurodegeneration J:233176
Tg(CAG-Ppard*E411P)#Als/0
Tg(Nes-cre)1Kln/0
B6J.Cg-Tg(Nes-cre)1Kln Tg(CAG-Ppard*E411P)#Als 		abnormal basal ganglion morphology J:233176
abnormal cerebral cortex morphology J:233176
abnormal mitochondrial ATP synthesis coupled electron transport J:233176
abnormal motor capabilities/coordination/movement J:233176
abnormal response to novel object J:233176
decreased body weight J:233176
decreased brain size J:233176
decreased dopaminergic neuron number J:233176
decreased exploration in new environment J:233176
decreased grip strength J:233176
decreased mitochondrial size J:233176
decreased neuron number J:233176
gliosis J:233176
impaired coordination J:233176
kyphosis J:233176
limb grasping J:233176
neurodegeneration J:233176
short stride length J:233176
Tg(Ckm-Ppard)MEDpk/0
involves: C57BL/6 * CBA 		abnormal muscle cell glucose uptake J:129848
impaired glucose tolerance J:129848
insulin resistance J:129848
Tg(Myh6-Ppard)HEDpk/0
involves: C57BL/6 * CBA 		abnormal response to cardiac infarction J:130750
normal cardiovascular system phenotype J:130750
decreased cardiac muscle contractility J:130750
decreased myocardial infarct size J:130750
increased cardiac muscle cell glucose uptake J:130750
increased cardiac muscle glycogen level J:130750
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory